Eur J Neurol:维生素D缺乏与低HDL-C的卒中患者预后不良相关

2016-10-31 MedSci MedSci原创

背景:目前的观察研究表明,较低的维生素D水平与缺血性脑卒中较差预后风险较高相关。这种相关性是否受血脂水平的影响还不清楚。研究者旨在调查血清维生素D,尤其是维生素D的缺乏对不同血脂水平的缺血性卒中预后的影响。方法:中国急性缺血性脑卒中的降压试验中纳入3181例缺血性患者,检测患者基线血清25 -羟维生素D水平。前瞻性地随访急性缺血性卒中后3个月患者死亡,主要的残疾和血管事件的发生。应用多变量logi

背景:目前的观察研究表明,较低的维生素D水平与缺血性脑卒中较差预后的风险较高相关。这种相关性是否受血脂水平的影响还不清楚。研究者旨在调查血清维生素D,尤其是维生素D的缺乏对不同血脂水平的缺血性卒中预后的影响。

方法:中国急性缺血性脑卒中的降压试验中纳入3181例缺血性患者,检测患者基线血清25 -羟维生素D水平。前瞻性地随访急性缺血性卒中后3个月患者死亡,主要的残疾和血管事件的发生。应用多变量logistic回归模型评估不同血脂水平亚组中,血清25羟维生素D水平和随访3个月缺血性脑卒中的临床预后的关系。

结果:维生素D缺乏与仅与高密度脂蛋白胆固醇(HDL-C)<1.04 mmol/L的患者,而不是所有缺血性卒中患者临床预后差相关。主要残疾和复合不良事件的多变量校正后的比值比(95%CI)分别为1.98(1.08-3.63),2.24(1.22-4.12)。维生素D和HDL-C水平对重大残疾和复合预后之间存在显著交互作用(相互作用P<0.05)。25羟维生素D水平与不良预后的风险之间存在显著的线性趋势(P = 0.03)。

结论:维生素D缺乏可能仅仅是低高密度脂蛋白胆固醇水平的缺血性脑卒中患者预后较差一个独立的危险因素。

原始出处:

Xu T, Zhong C, et al. Serum 25-hydroxyvitamin D deficiency predicts poor outcome amongst acute ischaemic stroke patients with low high density lipoprotein cholesterol. Eur J Neurol. 2016 Sep 19.


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    2017-01-11 yinhl1978
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    2016-11-04 1e137bdcm70(暂无匿称)

    知识更新很及时,学习了不少知识

    0

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    2016-11-03 保守主义

    嗯~又学习了

    0

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    2016-11-02 ZGMFX24A
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