Hum reprod update:妊娠并不能改善子宫内膜异位症的症状或延缓病程进展

2018-02-23 MedSci MedSci原创

子宫内膜异位症患者,常被建议妊娠,或许可有效控制其子宫内膜异位症的症状并减缓病程进展。因此,很多确诊子宫内膜异位症并准备怀孕的女性,对疾病和症状改善仍抱有希望。但是,关于妊娠对子宫内膜异位症的影响的研究结果存在争议,妊娠对子宫内膜异位症女性的症状改善没有明确关联。而且,越来越多的证据表明子宫内膜异位症可能会影响妊娠结局。Brigitte Leeners等人进行研究,对妊娠和哺乳期对妊娠前确诊的子宫

子宫内膜异位症患者,常被建议妊娠,或许可有效控制其子宫内膜异位症的症状并减缓病程进展。因此,很多确诊子宫内膜异位症并准备怀孕的女性,对疾病和症状改善仍抱有希望。但是,关于妊娠对子宫内膜异位症的影响的研究结果存在争议,妊娠对子宫内膜异位症女性的症状改善没有明确关联。而且,越来越多的证据表明子宫内膜异位症可能会影响妊娠结局。

Brigitte Leeners等人进行研究,对妊娠和哺乳期对妊娠前确诊的子宫内膜异位症的进展特征和症状是否存在有利影响进行评估。在PubMed上检索1966年-2017年5月发表的关于妊娠和子宫内膜异位症的文章。

本分析共纳入5个小规模的观察性研究(关于子宫内膜病变在妊娠期和妊娠后纵向变化)、11篇文献报道(妊娠期和产褥期对子宫内膜的监测)、22篇病例报道、6篇关于妊娠期子宫内膜损伤病理的研究和8篇关于妊娠对子宫内膜异位症早期发生和复发中的作用的研究。少有研究可用于评估妊娠和产褥期对子宫内膜异位症发展的影响。子宫内膜异位症的发展多变,未发现证据支持妊娠可减少子宫内膜异位病变的数量和大小。妊娠期病变的生长和结构变化可能是发生于蜕膜期。妊娠于子宫内膜异位症症状关联的相关结果,存有争议,且有强烈的偏见。

关于子宫内膜异位症在妊娠期和分娩后的变化的相关数据显示妊娠对子宫内膜异位症的正性作用比既往报道的更小。因此,当子宫内膜异位症女性准备怀孕时,不应被告知妊娠或可控制子宫内膜异位症的症状或延缓病程进展。

原始出处:

Brigitte Leeners, et al.The effect of pregnancy on endometriosis—facts or fiction?.Human Reproduction Update. February 15,2018. https://doi.org/10.1093/humupd/dmy004

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    2018-03-15 wxl882001

    学习一下

    0

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    2018-02-28 wxl882001

    学习一下

    0

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    2018-02-25 sunylz
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    2018-02-24 周周人

    学习.

    0

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    2018-02-24 131****1460

    学习了受益匪浅

    0

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