Biomaterials:3D打印Silk GMA水凝胶可促进软骨生长,或可用于临床软骨缺损的骨修复

2020-11-12 MedSci原创 MedSci原创

数字光处理(DLP)打印机的3D打印已进入再生医学组织工程的新浪潮。特别是在临床应用中,需要开发具有生物相容性、生物降解性和可打印性的生物墨水。本研究中,研究人员采用蚕丝纤维素作为一种天然聚合物,使用

数字光处理(DLP)打印机的3D打印已进入再生医学组织工程的新浪潮。特别是在临床应用中,需要开发具有生物相容性、生物降解性和可打印性的生物墨水。本研究中,研究人员采用蚕丝纤维素作为一种天然聚合物,使用缩水甘油酯-甲基丙烯酸酯(Silk-GMA)制造的DLP 3D打印。在体外培养系统中评估了含软骨细胞的Silk-GMA的软骨生成能力,并在体内应用,研究结果已在线发表于Biomaterials
结果显示,由于DLP 3D打印机的快速打印速度和光聚合作用,DLP 3D打印系统提供的3D产品细胞分布均匀。长达4周的Silk-GMA水凝胶体外培养可以确保封装细胞的活力、增殖和分化到软骨发育。此外,对部分缺损气管兔模型的体内实验表明,移植的Silk-GMA水凝胶周围发现了新的软骨样组织和上皮。
综上所述,该研究表明,利用DLP 3D打印机制造的Silk GMA水凝胶可应用于需要机械性能的组织工程领域,如软骨再生。
 
原始出处:
 
Heesun Hong, Ye Been Seo, et al., Digital light processing 3D printed silk fibroin hydrogel for cartilage tissue engineering. Biomaterials. 2020 Feb;232:119679.  doi: 10.1016/j.biomaterials.2019.119679.  

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    2021-10-14 sunylz
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    2021-10-05 axin020
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    2020-11-14 tastas
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    2020-11-14 lfcmxl
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    2020-11-14 lishizhe