J Endod:牙髓感染对心血管疾病发病机制的影响:一项使用GRADE进行meta分析的系统性回顾

2018-08-20 lishiting MedSci原创

这篇研究的目的是为了评估牙髓感染是否会对心血管疾病的发病机制存在影响。

这篇研究的目的是为了评估牙髓感染是否会对心血管疾病的发病机制存在影响。研究由2名独立的分析者进行复杂的文献搜索。从MEDLINE, Embase, Cochrane, and PubMed数据库中进行搜索。另外,也对参考书目、所有相关的灰色文献和教科书进行手动搜索。2名分析者之间没有任何冲突。结果显示,按照选择标准共有4篇文章具有高偏倚风险。其中对3篇文章进行了定性合成分析。所有这些文章均与心血管疾病(CVD)相关。较低的证据显示牙髓来源的损伤会导致系统性疾病,95%置信区间, 风险比1.2 (0.79-1.83)。基于各研究的高异质性,研究未进行亚组的分析。所有结果均有高度一致的风险比0.95 (0.75-1.21)以及均表现出低确定性。因此,作者认为效应估计的可靠性有限,结果效应有可能在实质上不同于估计效应。结论:对于是否牙髓来源的损伤会或不会对心血管疾病造成影响,证据水平不足,并且评估的可信性很低。这篇系统性的综述对数据的设计和分析提出疑问,认为还需要进一步的通过更加合理的纵向研究对这种因果关系进行论证。原始出处:Aminoshariae A, Kulild JC, et al.

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    2019-02-18 guojianrong
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    2018-10-19 一闲
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    2018-10-06 jxrzshh
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    2018-08-20 wanghx2006

    学习

    0

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