Circulation:减肥手术可显著降低有心血管疾病的肥胖患者的主要不良心血管事件的发生率

2021-04-20 MedSci原创 MedSci原创

减肥手术已被证实可显著降低心血管危险因素,但是,减肥手术是否也可以减少主要不良心血管事件?

减肥手术已被证实可显著降低血管危险因素。但是,减肥手术是否可以减少主要不良心血管事件(MACE),尤其是对于已确诊的心血管疾病患者,仍知之甚少。

本研究旨在确定合并心血管疾病的重度肥胖患者进行减肥手术与MACE之间的相关性

本研究是采用加拿大安大略省全省范围内多重链接的管理数据库进行的倾向得分匹配的队列研究。纳入既往接受减肥手术的有缺血性心脏病或心力衰竭病史的患者,并1:1匹配年龄、性别、心力衰竭病史以及倾向得分类似的对照个体。主义预后是MACE的发生率,包括全因死亡率、首次心肌梗死、冠脉重建、脑血管事件和心衰住院。次要预后指标包括3种MACE事件:心肌梗死、缺血性卒中和全因死亡率。

两组患者的预后

总体上,共纳入了2638位患者(每组各1319人)。中位随访4.6年后,减肥手术组的主要预后发生率为11.5%(151/1319),而对照组的是19.6%(259/1319;校正风险比[HR] 0.58,95% CI 0.48-0.71;p<0.001)。减肥手术与那些有心力衰竭病史(HR 0.44,95% CI 0.31-0.62,p<0.001;绝对风险差 19.3%,95% CI 12.0%-26.7%)和缺血性心脏病(HR 0.60,95% CI, 0.48–0.74,p<0.001;绝对风险差 7.5%,95% CI 4.7%–10.5%)患者的预后相关性最为显著。

此外,减肥手术还与次要预后(HR 0.66, 95% CI 0.52–0.84,p=0.001)和心血管死亡率(HR 0.35,95% CI 0.15–0.80,p=0.001)相关。

总之,减肥手术与合并心血管疾病的肥胖患者的MACE发生率降低相关

原始出处:

Aristithes G. Doumouras, et al. Bariatric Surgery and Cardiovascular Outcomes in Patients With Obesity and Cardiovascular Disease: A Population-Based Retrospective Cohort Study. Circulation. 2021;143:1468–1480. https://doi.org/10.1161/CIRCULATIONAHA.120.052386

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  5. 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  6. 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    2021-04-20 ms2000000321551178

    不错学习

    0

  7. 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createdAvatar=/v1.0.0/img/user_icon.png, createdBy=459a2862646, createdName=1664419569, createdTime=Tue Apr 20 11:36:13 CST 2021, time=2021-04-20, status=1, ipAttribution=)]
    2021-04-20 CHANGE

    什么时候有懒人用的减肥神药?

    0

  8. 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    2021-04-20 ms1000000056305151

    学习了!

    0

  9. 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    2021-04-20 ms4000000964498981

    心血管疾病要预防

    0

  10. 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    2021-04-20 1664419569

    体重管理对健康非常重要

    0

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