Gastroenterology:高级别组织学特征的小阴道息肉不会增加晚期结肠瘤形成的风险

2019-02-09 MedSci MedSci原创

随着内窥镜成像技术的进步,在内窥镜检查期间就可以区分腺瘤和增生性小的(1-5mm)息肉。然而,未能识别腺瘤(与增生性息肉相比)可能导致患者发生异常晚期肿瘤形成的低风险。因此,本项研究旨在探究息肉的早期组织学特征及其对于晚期肿瘤的风险。

背景与目的
随着内窥镜成像技术的进步,在内窥镜检查期间就可以区分腺瘤和增生性小的(1-5mm)息肉。然而,未能识别腺瘤(与增生性息肉相比)可能导致患者发生异常晚期肿瘤形成的低风险。因此,本项研究旨在探究息肉的早期组织学特征及其对于晚期肿瘤的风险。

方法
本项研究共纳入了30123名粪便免疫化学测试阳性的患者,并调取了他们结肠镜报告及病理学结果。异时性晚期肿瘤高风险患者被定义为具有晚期组织学特征(高度异型增生≥25%绒毛特征),3个或更多个小或(6-9 mm)非先进性腺瘤的息肉患者,或腺瘤或无柄锯齿状病变≥10mm。

结果
在51510个小型息肉中,在来自FIT队列的7.1%的患者和来自结肠镜检查队列的1.5%的患者中观察到了高级组织学特征(P  = .044); 然而,这种患病率的差异并未导致高风险患者比例的显着差异(P  = .25)。由于发现具有晚期组织学特征的小息肉而被发现具有异时性晚期肿瘤(17.6%)的高风险患者的比例与具有异时性晚期肿瘤的低风险患者(14.6%)的比例没有显着差异。

结论
本项研究的结果表明具有晚期组织学特征的小型息肉不会增加异时性晚期肿瘤形成的风险。

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    2019-08-26 许安
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