Allergy:即使是健康足月婴儿,花粉暴露也会增加其呼吸道症状风险

2022-03-23 小文子 MedSci原创

在出生后第一年,花粉暴露与呼吸道症状风险增加有关。

花粉暴露与儿童和成人的呼吸道症状有关。然而,花粉暴露与婴儿期呼吸系统症状之间的相关性仍不清楚。Allergy杂志的一项研究探索了花粉暴露与婴儿期呼吸道症状的相关性,以及母亲特应症、婴儿性别或空气污染是否会改变这种联系。

研究调查了前瞻性出生队列BILD队列401名健康足月婴儿的14874个测量时间点。婴儿期,每周通过电话访谈评估白天和夜间的呼吸道症状(咳嗽、喘息、呼吸困难),用标准化的5分类严重程度评分(0-4)评估呼吸道症状的严重程度,0表示没有症状和评分≥1表明症状越来越严重。所有环境暴露(花粉浓度、PM2.5、NO2、温度、相对湿度)与婴儿居住地有关。评估花粉暴露与呼吸道症状之间的关系,以及母亲特应性、婴儿性别和空气污染(NO2、PM2.5)对效应的影响。空气污染数据仅在2005年1月1日至2017年1月1日期间可用,花粉数据仅限于这一时间段1月至9月。

结果显示,所有年份分析期间(1月~9月),日间呼吸道症状为0.13±0.13,夜间呼吸道症状为0.12±0.14。花粉暴露与日间呼吸道症状(10%花粉/m3:混合花粉RR=1.006[1.002,1.009];树花粉RR=1.005[1.002,1.008];草花粉RR=1.009[1.000,1.23])和夜间呼吸道症状(混合花粉1.003[0.999,1.007];树花粉1.003[0.999,1.007];草花粉1.014[1.004,1.024])增加有关。结果发现,混合花粉与母亲特应症和婴儿性别之间没有相互作用,但发现了混合花粉和PM2.5之间的复杂交互作用(p=0.002)。

在出生后第一年,花粉暴露与呼吸道症状风险增加有关,而与母亲特应症和婴儿性别无关。由于婴儿期是肺部发育特别脆弱的时期,花粉暴露的不良影响可能与儿童慢性哮喘的演变有关。

原文出处:

Amanda Gisler, Marloes Eeftens, et al, Pollen exposure is associated with risk of respiratory symptoms during the first year of life, Allergy, 2022, doi: 10.1111/ALL.15284.

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    2022-03-23 Jessica

    #学习#花粉过敏患者,鼻炎

    0

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    2022-03-23 zhmscau
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    2022-03-23 膀胱癌
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目前,慢性阻塞性肺疾病(COPD)的诊断需要1秒用力呼气容积(FEV1)与小于0.70的用力肺活量(FVC)(通过支气管扩张剂使用后通过肺活量评估)的比值来确定。然而,很多吸烟者不符合有呼吸道症状的定义。原始出处:Prescott G. Woodruff,Graham Barr,Eugene Bleecker,et al.Clinical Significance of Symptoms in S