JCEM:妊娠期糖尿病孕妇锌含量与婴儿出生体重的关系

2020-04-15 MedSci原创 MedSci原创

在锌摄入量不足的人群中,GDM可能会改变MB和CB锌含量与出生体重之间的关联。

锌(Zn)被认为会影响胎儿生长。然而,妊娠期糖尿病(GDM)由于其对胎儿生长和胎盘运输的影响,可能会使这种效应复杂化。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在探讨GDM是否能改变锌水平与婴儿出生体重之间的关系。

研究人员于2012-2016年期间在中国太原市建立了一个与GDM匹配的队列,包括752例GDM患者和744例非GDM患者。研究人员对妊娠期间的饮食锌摄入量进行了评估,同时测定了孕妇血(MB)和脐带血(CB)中锌含量。出生体重被标准化为z评分,分为高(HBW>4000g)和低(LBW<2500g)出生体重组。研究人员采用多变量线性回归和多变量Logistic回归的方法分析了患有或不患有GDM的孕妇所生子女的锌水平与出生体重之间的关系。

88.8% (N=1328)的受试者在妊娠期间锌摄入量不足。GDM女性MB锌含量与出生体重呈负相关(β=-0.17,95%可信区间(CI)为-0.34至-0.01),而CB锌含量与出生体重呈正相关(β=0.38,95%CI为0.06-0.70);提示MB的Zn含量与LBW之间(比值比为2.01,95%CI为0.95-4.24)和CB的Zn含量与HBW之间(比值比为2.37,95%CI为1.08-5.21)存在相关性。

由此可见,在锌摄入量不足的人群中,GDM可能会改变MB和CB锌含量与出生体重之间的关联。

原始出处:

Jiajun Luo.et al.Zinc levels and birth weight in pregnant women with gestational diabetes mellitus: a matched cohort study in China.J Clin Endocrinol Metab.2020.https://doi.org/10.1210/clinem/dgaa171

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    2020-09-11 achengzhao
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    2020-11-13 smallant2015
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    2020-04-15 misszhang

    谢谢MedSci提供最新的威廉亚洲官网

    0

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正常妊娠时,随着肾素和血管紧张素II的增加,血浆中盐皮质激素醛固酮增多,在生理血浆体积膨胀中起着重要作用。在小鼠中,醛固酮通过促进胎盘生长因子(PlGF)表达和滋养细胞增殖,促进胎儿发育。子痫前期时,同时发生醛固酮抑制与胎盘发育障碍。Anna Birukov等人推测醛固酮对人类胎盘和胎儿出生体重有独立的影响,而高钠和低钾的饮食会负性影响这种关系。为了验证上述推测,研究人员对以丹麦人群为基础的一个队

Thyroid:孕妇暴露于PM2.5及其成分对母亲和新生儿甲状腺功能和出生体重的影响

由此可见,该研究的结果表明孕妇暴露于PM2.5及其成分与孕妇fT4水平之间呈负相关。孕妇fT4可能作为暴露于PM2.5及其成分和出生体重之间相关性的介导因素。