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Radiology：氟MRI在高强度聚焦超声消融术后评估肿瘤炎症反应的价值

2018-02-26 shaosai MedSci原创

氟19高强度聚焦超声巨噬细胞
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本研究旨在探究是否氟19（ 19F）磁共振（MR）成像能够定量评估高强度聚焦超声（HIFU）诱导下巨噬细胞浸润，研究人员将结果发表在Radiology上。

本研究旨在探究是否氟19（ 19F）磁共振（MR）成像能够定量评估高强度聚焦超声（HIFU）诱导下巨噬细胞浸润，研究人员将结果发表在Radiology上。

本研究共将皮下接种4T1细胞的BALB/c小鼠分为三组：未治疗组（对照组，n=9）、HIFU治疗组(HIFU， n = 9)和HIFU联合氯磷酸盐治疗组(HIFU+Clod， n = 9)。在HIFU治疗后，所有小鼠均静脉注射全氟化碳（PFC）乳化液。在HIFU治疗后2、4、7、10、和14天进行MR成像扫描。利用双因子重复测量方差分析分析19F新高改变以及组间差异。进行组织学检查进行确认。

结果为，氟19信号出现在肿瘤的边缘及消融病变周边。到了第4天，HIFU治疗组肿瘤平均氟19信号要显着高于对照组(0.82 ± 0.26 vs 0.42 ± 0.17， P < .001)。从第4天到14天，在HIFU+Clod组F19信号要明显高于対照组。组织学检查表明消融周边有巨噬细胞浸润。免疫荧光染色发现PFC标记的巨噬细胞。

本研究表明，氟19 MR成像能够纵向获取及定量评价临床前肿瘤模型中HIFU诱导的巨噬细胞浸润。

原始出处：

Shin SH， Park SH， Kim SW. et al.Fluorine MR Imaging Monitoring of Tumor Inflammation after High-Intensity Focused Ultrasound Ablation.Radiology.DOI： 10.1148/radiol.2017171603

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    #消融术#

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  6. [GetPortalCommentsPageByObjectIdResponse(id=2055074, encodeId=dd6d20550e454, content=<a href='/topic/show?id=6b148082247' target=_blank style='color:#2F92EE;'>#聚焦超声#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80822, encryptionId=6b148082247, topicName=聚焦超声)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Thu Jan 03 10:23:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1320849, encodeId=02cd132084907, content=<a href='/topic/show?id=43de6e0076f' target=_blank style='color:#2F92EE;'>#炎症反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67007, encryptionId=43de6e0076f, topicName=炎症反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b73f484, createdName=lsj628, createdTime=Wed Feb 28 09:23:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421707, encodeId=20921421e0726, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Wed Feb 28 09:23:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560259, encodeId=cb1e15602597a, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Wed Feb 28 09:23:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566268, encodeId=e5eb15662689f, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Wed Feb 28 09:23:00 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604015, encodeId=6bc3160401592, content=<a href='/topic/show?id=67b81023e6ea' target=_blank style='color:#2F92EE;'>#高强度#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102376, encryptionId=67b81023e6ea, topicName=高强度)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=79d219134728, createdName=aids219, createdTime=Wed Feb 28 09:23:00 CST 2018, time=2018-02-28, status=1, ipAttribution=)]
    2018-02-28 aids219

    #高强度#

    0