Am J Med.:妊娠期阿片类药物使用很“伤心”

2018-01-19 梁舒瑶 环球医学

2018年1月,发表在《Am J Med》的一项由美国科学家进行的研究考察了美国妊娠女性中,阿片类药物使用与急性心脏事件之间的相关性。

2018年1月,发表在《Am J Med》的一项由美国科学家进行的研究考察了美国妊娠女性中,阿片类药物使用与急性心脏事件之间的相关性。

背景:心血管疾病仍是美国妊娠相关死亡的主要原因。妊娠女性中阿片类药物使用的增加造成的致命性心血管事件未知。研究者考察了过去十年里,妊娠女性阿片类药物使用的趋势,以及阿片类药物使用暂时趋势的变化与母亲急性心脏事件发生率的之间相关性。

方法:在对健康医疗和成本使用项目(Healthcare and Cost Utilization Project)的回顾性分析中,研究者使用2002年1月1日至2014年12月31日期间,从非联邦医院出院的全部住院患者中的2个阶段的分层集群样本。研究人群由年龄在13至49岁的妊娠女性构成,以及相关住院,包括生产。主要暴露为妊娠期阿片类的使用。主要结局为妊娠期或分娩期急性心梗或心脏骤停的发生率。

结果:在5740万次妊娠相关住院中,511469例(约1%)有阿片类药物、可卡因和/或安非他明使用记录。研究期间,妊娠期阿片类使用增加300%,而可卡因的使用显着降低,安非他明的使用保持稳定。在13年中,母亲阿片类使用的增加伴随着急性心脏事件发生率增加50%。

结论:在过去十年,妊娠期阿片类的使用显着增加,同时妊娠和分娩中急性心脏事件发生率增加。需要有效的国家政策来应对这一新的公共健康挑战。

原始出处:
Salihu HM, Salemi JL, Aggarwal A,et al.Opioid Drug Use and Acute Cardiac Events Among Pregnant Women in the United States.Am J Med. 2018 Jan;131(1):64-71.e1. doi: 10.1016/j.amjmed.2017.07.023. Epub 2017 Aug 12.

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    2018-01-21 lhlxtx
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