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Radiology： 68Ga-PSMA-11 PET/MRI与多参数MRI诊断前列腺癌哪个更好？

2018-12-04 shaosai MedSci原创

前列腺特异性膜抗体前列腺癌MRI
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本研究旨在比较68Ga-前列腺特异性膜抗体（PSMA-11）PET/MRI与多参数MRI诊断前列腺癌的准确性。

本研究旨在比较68Ga-前列腺特异性膜抗体（PSMA-11）PET/MRI与多参数MRI诊断前列腺癌的准确性。

本研究回顾性分析了活检证实为前列腺癌并于根治性前列腺切除术前行 68Ga-PSMA-11 PET/MRI的患者。参考标准为大组组切片病理结果。阅片者对影像学和病理学结果未知。基于30解剖区域对肿瘤进行定位。利用原始stringent and alternative neighboring法计算 68Ga-PSMA-11 PET/MRI和多参数MRI基于区域的敏感性和特异性。与肿瘤Gleason评分比较，比较最大标准化摄取量(SUVmax)和PI-RADS第二版分级。利用广义估计方程评价总体平均敏感性、特异性，并验证肿瘤特征和SUVmax或 PI-RADS评分的相关性。

结果为，共有32例患者纳入研究。PET/MRI和多参数MRI的基于区域特异的敏感性分别为74% (95%CI： 70%， 77%)、50% (95% CI： 45%， 0.54%)与73% (95% CI： 68%， 79%)、69% (95% CI： 62%， 75%)。在选择相邻方法中，PET/MRI与多参数MRI的基于区域敏感性相似(88% [95% CI： 85%， 91%] vs 90% [95% CI： 87%， 92%]， P = .99)；在总体平均方法评估中，两者为(70% [95% CI： 64%， 76%] vs 70% [95% CI： 64%， 75%]， P = .99)。SUVmax 与Gleason评分≥7具有相关性(OR： 1.71 [95% CI： 1.27， 2.31]， P < .001)。

本研究表明，68Ga-PSMA-11 PET/MRI在诊断前列腺癌中要优于多参数MRI。

原始出处：

Hicks RM， Simko JP， Westphalen AC，et al.Diagnostic Accuracy of 68Ga-PSMA-11 PET/MRI Compared with Multiparametric MRI in the Detection of Prostate Cancer.Radiology.DOI：10.1148/radiol.2018180788

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    2019-10-07 circumcision

    #PET/MRI#

    0

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    2019-04-13 feather89

    #PE#

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    2018-12-06 ms7514935887898259

    #PET#

    0

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    2018-12-06 江川靖瑶

    #SMA#

    0

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    2018-12-04 医者仁心5538

    学习了

    0