Clin Nutr:溃疡性结肠炎的身体成分变化研究

2016-11-14 MedSci MedSci原创

溃疡性结肠炎(UC)患者的身体成分仍不清楚。这项研究评估了成年UC患者的身体成分,以及身体成分与疾病活动性和外科干预之间的关联。 这项研究包括99例UC患者,105例克罗恩氏病(CD)患者,以及60名对照组。通过腹部CT评估骨骼肌面积(SMA)、内脏脂肪面积(VFA)和皮下脂肪面积(SFA)(第三腰椎处)。调查了内科治疗和外科手术治疗对UC患者身体组分的影响。 UC患者与对照组比较,更

溃疡性结肠炎(UC)患者的身体成分仍不清楚。这项研究评估了成年UC患者的身体成分,以及身体成分与疾病活动性和外科干预之间的关联。

这项研究包括99例UC患者,105例克罗恩氏病(CD)患者,以及60名对照组。通过腹部CT评估骨骼肌面积(SMA)、内脏脂肪面积(VFA)和皮下脂肪面积(SFA)(第三腰椎处)。调查了内科治疗和外科手术治疗对UC患者身体组分的影响。

UC患者与对照组比较,更容易出现肌肉减少症(27.3% vs 8.3%),但是比CD患者(59.0%)的肌肉减少症比例少。UC患者中,高Mayo分数(≥6)与低Mayo分数(<6)者比较,肌肉减少症的患病率明显更高(33.8% vs. 4.5%, p < 0.001)、SMA (144.26 vs. 182.32 cm2, p < 0.001)和骨骼肌指数(SMI) (52.22 vs. 65.52 cm2/m2, p < 0.001)明显更低。不过SFA和VFA是相似的。肌肉减少症的患病率与身体成分的改变呈反相关。SMA和SMI与UC患者的疾病活动度明显相关。多变量分析表明,肌肉减少症(OR 8.49; 95% CI, 1.80-40.10; p = 0.007)是UC患者高Mayo分数的消极因素。Kaplan Meier生存曲线显示,肌肉减少症患者同时有UC,结肠切除术的可能性增高。

肌肉减少症与UC患者较高的疾病活动度和不良临床预后相关。内科和外科手术治疗对肌肉减少症和骨骼肌消耗患者有积极作用。

原始出处:

Zhang T1, Ding C,et al.Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy.Clin Nutr. 2016 Oct 19. pii: S0261-5614(16)31276-6.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1694976, encodeId=329516949e6bb, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Jan 04 10:46:00 CST 2017, time=2017-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158441, encodeId=c60415844181, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 27 08:46:39 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156495, encodeId=403715649559, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Nov 18 00:09:13 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537407, encodeId=adf4153e407c4, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Wed Nov 16 10:46:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156079, encodeId=397a1560e9f4, content=自己为此病困扰,学习了,获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230812/e93037ddfed9425fb0316dc3e904f2f4/870c0a4383ef42ef803173fea0339be3.jpg, createdBy=27ba1551982, createdName=huangzh898, createdTime=Wed Nov 16 10:11:58 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155764, encodeId=03d9155e64a0, content=如果能够结合患者个体化营养状态进行相关性分析可能更有意义!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825824F0A19A1764.jpg, createdBy=edeb1422421, createdName=yxtcm.best, createdTime=Mon Nov 14 22:46:51 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2017-01-04 nymo
  2. [GetPortalCommentsPageByObjectIdResponse(id=1694976, encodeId=329516949e6bb, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Jan 04 10:46:00 CST 2017, time=2017-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158441, encodeId=c60415844181, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 27 08:46:39 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156495, encodeId=403715649559, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Nov 18 00:09:13 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537407, encodeId=adf4153e407c4, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Wed Nov 16 10:46:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156079, encodeId=397a1560e9f4, content=自己为此病困扰,学习了,获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230812/e93037ddfed9425fb0316dc3e904f2f4/870c0a4383ef42ef803173fea0339be3.jpg, createdBy=27ba1551982, createdName=huangzh898, createdTime=Wed Nov 16 10:11:58 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155764, encodeId=03d9155e64a0, content=如果能够结合患者个体化营养状态进行相关性分析可能更有意义!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825824F0A19A1764.jpg, createdBy=edeb1422421, createdName=yxtcm.best, createdTime=Mon Nov 14 22:46:51 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2016-11-27 李东泽

    很好,不错,以后会多学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1694976, encodeId=329516949e6bb, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Jan 04 10:46:00 CST 2017, time=2017-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158441, encodeId=c60415844181, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 27 08:46:39 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156495, encodeId=403715649559, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Nov 18 00:09:13 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537407, encodeId=adf4153e407c4, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Wed Nov 16 10:46:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156079, encodeId=397a1560e9f4, content=自己为此病困扰,学习了,获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230812/e93037ddfed9425fb0316dc3e904f2f4/870c0a4383ef42ef803173fea0339be3.jpg, createdBy=27ba1551982, createdName=huangzh898, createdTime=Wed Nov 16 10:11:58 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155764, encodeId=03d9155e64a0, content=如果能够结合患者个体化营养状态进行相关性分析可能更有意义!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825824F0A19A1764.jpg, createdBy=edeb1422421, createdName=yxtcm.best, createdTime=Mon Nov 14 22:46:51 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2016-11-18 1e0ece0dm09(暂无匿称)

    谢谢分享学习

    0

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    2016-11-16 huangzh898

    自己为此病困扰,学习了,获益匪浅!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1694976, encodeId=329516949e6bb, content=<a href='/topic/show?id=c76e6645438' target=_blank style='color:#2F92EE;'>#溃疡性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66454, encryptionId=c76e6645438, topicName=溃疡性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=787129789891, createdName=nymo, createdTime=Wed Jan 04 10:46:00 CST 2017, time=2017-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158441, encodeId=c60415844181, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Nov 27 08:46:39 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156495, encodeId=403715649559, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K46ZAxBHmHsph32KkfsWGwmickB6RsCUD8KruE4vo5CpvXfdu16GBpp4ibh6WJu1o9iatP1LWKDmvmic/0, createdBy=be6f1940165, createdName=1e0ece0dm09(暂无匿称), createdTime=Fri Nov 18 00:09:13 CST 2016, time=2016-11-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537407, encodeId=adf4153e407c4, content=<a href='/topic/show?id=b1f09320892' target=_blank style='color:#2F92EE;'>#身体成分#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93208, encryptionId=b1f09320892, topicName=身体成分)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a2ac12863902, createdName=chengjn, createdTime=Wed Nov 16 10:46:00 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156079, encodeId=397a1560e9f4, content=自己为此病困扰,学习了,获益匪浅!, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20230812/e93037ddfed9425fb0316dc3e904f2f4/870c0a4383ef42ef803173fea0339be3.jpg, createdBy=27ba1551982, createdName=huangzh898, createdTime=Wed Nov 16 10:11:58 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155764, encodeId=03d9155e64a0, content=如果能够结合患者个体化营养状态进行相关性分析可能更有意义!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161111/IMG5825824F0A19A1764.jpg, createdBy=edeb1422421, createdName=yxtcm.best, createdTime=Mon Nov 14 22:46:51 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2016-11-14 yxtcm.best

    如果能够结合患者个体化营养状态进行相关性分析可能更有意义!

    0

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