Biol Psychiatry:中国太极拳可改善老年性失眠

2015-10-23 MedSci MedSci原创

背景:已知睡眠障碍与全身细胞的炎症反应有关,同时也包括单核细胞的炎症反应。而这些相关治疗失眠的手段是否可以逆转这些老年人失眠的标志物还未得知。 方法:在这些随机试验中,123例老年性失眠患者被随机分为认知行为疗法组(CBT-I),太极拳组(TCC),以进行睡眠研讨教育作为对照组,即进行4个月的每周超过2个小时的教育课程,在之后的7、16个月时做随访。研究人员在基线和4和16个月时,测量C-反

背景:已知睡眠障碍与全身细胞的炎症反应有关,同时也包括单核细胞的炎症反应。而这些相关治疗失眠的手段是否可以逆转这些老年人失眠的标志物还未得知。

方法:在这些随机试验中,123例老年性失眠患者被随机分为认知行为疗法组(CBT-I),太极拳组(TCC),以进行睡眠研讨教育作为对照组,即进行4个月的每周超过2个小时的教育课程,在之后的7、16个月时做随访。研究人员在基线和4和16个月时,测量C-反应蛋白(C-反应蛋白);在基线和2、4、7个月时,测炎性细胞因子产生的16TLR4激活单核细胞;在基线和4个月时,测全基因组转录谱。

结果:与睡眠研讨教育活动控制条件相比,CBT-I组的CPR水平减小(4、6个月,P<.05),促炎细胞因子的单核细胞生成(仅2个月, p < .05),促炎基因表达(4个月,P<.05)。
TCC组的C-反应蛋白轻微降低(4个月,P = .06),促炎细胞因子的单核细胞生成显著减少(在2、4、7和16个月,P<.05),促炎基因表达(4个月,P<.001)。在CBT-1和TCC组中,用TELiS promoter-based生物信息学分析后显示核因子-κβ和AP-1的活力减少。

结论:老年性失眠的认知行为疗法可降低全身炎症反应,太极拳能减少单核细胞炎症反应,两种治疗法均可降低炎性基因的表达。这个发现为了解治疗炎症失眠的潜在有益的作用与炎症性疾病风险的影响,提供了循证医学的分子框架。

原始出处:


Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Bootzin R, Cole S.Cognitive Behavioral Therapy and Tai Chi Reverse Cellular and Genomic Markers of Inflammation in Late Life Insomnia: A Randomized Controlled Trial.Biol Psychiatry. 2015 Feb 4. pii: S0006-3223(15)00079-7. 

Irwin MR, Olmstead R, Breen EC, Witarama T, Carrillo C, Sadeghi N, Arevalo JM, Ma J, Nicassio P, Ganz PA, Bower JE, Cole S.Tai chi, cellular inflammation, and transcriptome dynamics in breast cancer survivors with insomnia: a randomized controlled trial.J Natl Cancer Inst Monogr. 2014 Nov;2014(50):295-301.

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    2016-11-07 帅哥挺住

    good

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    2015-12-16 steven_u9
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    2016-08-07 sunylz
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    2016-03-07 忠诚向上

    好好学习,继续努力

    0

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    2016-03-07 忠诚向上

    好好学习,继续努力

    0

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    2016-03-07 忠诚向上

    好好学习,继续努力

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=154089, encodeId=ad6c15408951, content=good, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3jgw8RjjxopibVpFrR95fNbaDia2Ok1Q1qhA89ia1AYRl1AQmlpSfJeRebr7FUlWSF0VWJ7sPhgatfiaOVicuzFPw4R/0, createdBy=58031944211, createdName=帅哥挺住, createdTime=Mon Nov 07 14:39:28 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766976, encodeId=18a51e66976da, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Nov 19 14:14:00 CST 2015, time=2015-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632112, encodeId=0ece1632112f5, content=<a href='/topic/show?id=34c74421593' target=_blank style='color:#2F92EE;'>#太极#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44215, encryptionId=34c74421593, topicName=太极)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec5221859655, createdName=steven_u9, createdTime=Wed Dec 16 22:14:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917206, encodeId=d55f191e20653, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Aug 07 08:14:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68080, encodeId=1e816808043, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68075, encodeId=8d55680e57d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68076, encodeId=fdfc680e617, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68077, encodeId=50ac680e75d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68078, encodeId=9d5e680e8fa, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68079, encodeId=4a4a680e91e, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=)]
    2016-03-07 忠诚向上

    好好学习,继续努力

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=154089, encodeId=ad6c15408951, content=good, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3jgw8RjjxopibVpFrR95fNbaDia2Ok1Q1qhA89ia1AYRl1AQmlpSfJeRebr7FUlWSF0VWJ7sPhgatfiaOVicuzFPw4R/0, createdBy=58031944211, createdName=帅哥挺住, createdTime=Mon Nov 07 14:39:28 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766976, encodeId=18a51e66976da, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Nov 19 14:14:00 CST 2015, time=2015-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632112, encodeId=0ece1632112f5, content=<a href='/topic/show?id=34c74421593' target=_blank style='color:#2F92EE;'>#太极#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44215, encryptionId=34c74421593, topicName=太极)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec5221859655, createdName=steven_u9, createdTime=Wed Dec 16 22:14:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917206, encodeId=d55f191e20653, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Aug 07 08:14:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68080, encodeId=1e816808043, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68075, encodeId=8d55680e57d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68076, encodeId=fdfc680e617, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68077, encodeId=50ac680e75d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68078, encodeId=9d5e680e8fa, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68079, encodeId=4a4a680e91e, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=)]
    2016-03-07 忠诚向上

    好好学习,继续努力

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=154089, encodeId=ad6c15408951, content=good, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3jgw8RjjxopibVpFrR95fNbaDia2Ok1Q1qhA89ia1AYRl1AQmlpSfJeRebr7FUlWSF0VWJ7sPhgatfiaOVicuzFPw4R/0, createdBy=58031944211, createdName=帅哥挺住, createdTime=Mon Nov 07 14:39:28 CST 2016, time=2016-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1766976, encodeId=18a51e66976da, content=<a href='/topic/show?id=64f5343e2f' target=_blank style='color:#2F92EE;'>#Biol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3437, encryptionId=64f5343e2f, topicName=Biol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=446937890434, createdName=12498ebem31暂无昵称, createdTime=Thu Nov 19 14:14:00 CST 2015, time=2015-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632112, encodeId=0ece1632112f5, content=<a href='/topic/show?id=34c74421593' target=_blank style='color:#2F92EE;'>#太极#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44215, encryptionId=34c74421593, topicName=太极)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec5221859655, createdName=steven_u9, createdTime=Wed Dec 16 22:14:00 CST 2015, time=2015-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917206, encodeId=d55f191e20653, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sun Aug 07 08:14:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68080, encodeId=1e816808043, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68075, encodeId=8d55680e57d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68076, encodeId=fdfc680e617, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68077, encodeId=50ac680e75d, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68078, encodeId=9d5e680e8fa, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=68079, encodeId=4a4a680e91e, content=好好学习,继续努力, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Mon Mar 07 19:53:00 CST 2016, time=2016-03-07, status=1, ipAttribution=)]
    2016-03-07 忠诚向上

    好好学习,继续努力

    0

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