中华内科杂志:肝素诱导的血小板减少症发病率及其抗体阳性率调查

2013-09-17 晓静 摘编 医学论坛网

中日友好医院血液科高亚玥和中国医学科学院北京协和医学院北京协和医院住院赵永强、王书杰探讨了患者肝素诱导的血小板减少症(HIT)发病率和HIT抗体阳性率及相关临床因素。结果表明,肝素制剂应用人群中HIT的发病率和HIT抗体阳性率不低,且均与病种有关。HIT抗体检测在4Ts评分高可能性患者中的临床应用价值更大。相关论文发表于2013年第9期《中华内科杂志》。 研究者们选取了应用肝素制剂的患者

中日友好医院血液科高亚玥和中国医学科学院北京协和医学院北京协和医院住院赵永强、王书杰探讨了患者肝素诱导的血小板减少症(HIT)发病率和HIT抗体阳性率及相关临床因素。结果表明,肝素制剂应用人群中HIT的发病率和HIT抗体阳性率不低,且均与病种有关。HIT抗体检测在4Ts评分高可能性患者中的临床应用价值更大。相关论文发表于2013年第9期《中华内科杂志》。【原文下载】

研究者们选取了应用肝素制剂的患者197例(男120例、女77例),进行4Ts评分(Pretest Clinical Scoring System)及应用酶联免疫吸附试验(ELISA)检测HIT抗体,并按4Ts评分及病种分组、分别统计HIT发病率及HIT抗体阳性率。


结果显示,HIT总发病率为3.0%(6/197);HIT抗体总阳性率为12.2%(24/197),抗体阳性率在4Ts评分低、中、高可能性组分别为10.1%(18/178)、7.7%(1/13)、83.3%(5/6)。HIT抗体阳性率和抗体检测平均值,在高可能性组与低、中可能性组之间差异均有统计学意义(P值均=0.000)。HIT发病率及HIT抗体阳性率均为外科高于内科(5.8%比0.9%,P=0.047;19.8%比6.3%,P=0.004)。

原文下载

GAO Ya-yue,ZHAO Yong-qiang,WANG Shu-jie.The incidence of heparin-induced   thrombocytopenia and positivity of antibody in patients treated with heparin  preparations [J]. Chin J Intern Med, 2013, 52(9): 734-736.



    

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    2020-09-14 辣妈

    太难了

    0

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