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Clinica Chimica Acta：乙型肝炎病毒基因型的抗乙型肝炎疫苗单克隆抗体的免疫反应模式

2020-08-09 MedSci原创 MedSci原创

乙型肝炎病毒；基因型
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乙型肝炎表面抗原(HBsAg)特异性单克隆抗体(mAbs)是潜在的有价值的治疗和诊断工具。

乙型肝炎表面抗原(HBsAg)特异性单克隆抗体(mAbs)是潜在的有价值的治疗和诊断工具。本研究之前建立并鉴定了一组来自免疫BALB/c小鼠的单克隆抗体，这些单克隆抗体由酵母衍生的重组HB疫苗subgentoype A2和HBsAg亚型adw2组成。本研究采用世界卫生组织(WHO)第一个HBV基因型参考面板，包括15份亚基因型A1、A2、B1、B2、C2、D1-D3、E、F2和H的血清样本，评价该HBV不同基因型和亚基因型的anti-HBs单克隆抗体面板的反应模式。

21种抗HBs mAb中有10种能够强烈识别WHO参考组中提供的所有HBsAg基因型/亚型。但是，在21种抗HBs mAb中，有10种显示出与HBV基因型/ HBsAg亚型D2 / ayw3，E / ayw4，F2 / adw4和H / adw4的反应性中度至深度丧失。第二组中的两个mAb与3个C2 / adr基因型/亚型样品中只有1个的反应性大大降低。这三个样品的氨基酸比对表明该特定样品在位于“ a”决定簇内的残基127处包含氨基酸取代。以前仅在D / ayw3，E / ayw4，F / adw4和H中报道了这种氨基酸替代，它极大地影响了抗HBs​​抗体的反应性。有趣的是，该WHO样本中样品的氨基酸比对结果表明，在C2 / adr中也可以找到P127T取代基。比较抗原环（AGL）内的氨基酸序列，发现D2 / ayw3包含T118A / P127T双取代，E / ayw4包含P127L / T140S，F2 / adw4包含P127L / T140S / F158L，H / adw4包含P127L取代。因此，氨基酸在118、127、140和158位点的变异被发现与anti-HBs单克隆抗体的反应性显著降低。

由于不同基因型HBV的HBsAg变异程度会深刻影响anti-HBs单克隆抗体的反应性，因此，HBsAg检测的分析敏感性应根据相关国家流行的和常见的HBV变异来考虑。

原始出处：

Forough Golsaz-Shirazi，Sahar Asadi-Asadabad，Immunoreactivity pattern of monoclonal antibodies against Hepatitis B vaccine with global Hepatitis B virus genotypes

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    2021-01-25 okhuali

    #乙型肝炎#

    0

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    2020-12-03 aids221

    #克隆#

    0

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    2021-05-04 windight

    #CTA#

    0

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    2020-09-12 kzlchina

    #基因型#

    0

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    2020-08-11 cnxcy

    #免疫反应#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1825730, encodeId=c9cb1825e300a, content=<a href='/topic/show?id=1a942339426' target=_blank style='color:#2F92EE;'>#乙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23394, encryptionId=1a942339426, topicName=乙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ea6321, createdName=okhuali, createdTime=Mon Jan 25 19:48:51 CST 2021, time=2021-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1660223, encodeId=7302166022389, content=<a href='/topic/show?id=8d0d28912db' target=_blank style='color:#2F92EE;'>#克隆#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28912, encryptionId=8d0d28912db, topicName=克隆)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596825099872, createdName=aids221, createdTime=Thu Dec 03 06:48:51 CST 2020, time=2020-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850024, encodeId=2e59185002436, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Tue May 04 11:48:51 CST 2021, time=2021-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1890876, encodeId=5e7518908e640, content=<a href='/topic/show?id=742341e1782' target=_blank style='color:#2F92EE;'>#基因型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41717, encryptionId=742341e1782, topicName=基因型)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f984116, createdName=kzlchina, createdTime=Sat Sep 12 07:48:51 CST 2020, time=2020-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280226, encodeId=3982128022628, content=<a href='/topic/show?id=2bbe289846f' target=_blank style='color:#2F92EE;'>#免疫反应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28984, encryptionId=2bbe289846f, topicName=免疫反应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=827b160, createdName=cnxcy, createdTime=Tue Aug 11 13:48:51 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351569, encodeId=d0be13515693e, content=<a href='/topic/show?id=74672339e92' target=_blank style='color:#2F92EE;'>#乙型肝炎病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23397, encryptionId=74672339e92, topicName=乙型肝炎病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Aug 11 13:48:51 CST 2020, time=2020-08-11, status=1, ipAttribution=)]
    2020-08-11 zhaojie88

    #乙型肝炎病毒#

    0