Oncotarget:术前白蛋白/球蛋白比例能够预测喉鳞状细胞癌患者预后

2017-08-23 Emma MedSci原创

喉鳞状细胞癌(LSCC)是头颈部第二高发的鳞状细胞癌,虽然吸烟、饮酒、喉咽反流等被考虑为其危险因素,但病因至今尚不明确。

鳞状细胞癌简称鳞癌,又称表皮样癌,常发生在身体原有鳞状上皮覆盖的部位,此类癌肿恶性程度较基底细胞癌者为高。发展较快,破坏也较大。即可破坏眼部组织,侵入副鼻窦或颅内,又可以通过淋巴管转移至耳前或颌下淋巴结,甚至引起全身性转移。喉鳞状细胞癌(LSCC)是头颈部第二高发的鳞状细胞癌,虽然吸烟、饮酒、喉咽反流等被考虑为其危险因素,但病因至今尚不明确。

研究人员回顾性分析了术前白蛋白/球蛋白比例(AGR)在喉鳞状细胞癌(LSCC)中的预测价值,这在之前的相关研究中尚未报道过。研究结果显示,术前AGR是一种可作为预测LSCC患者预后的有价值且易于评估的血液指标。

其中,研究时间范围为2005年1月至2010年12月,纳入南昌大学第二附属医院241例新诊断的LSCC患者。确定总生存期(OS)的最佳AGR截止值为1.28。单变量生存分析显示性别、低AGR、T分类、组织学分级和淋巴结转移是与OS差异相关的因素;低水平的AGR、T分类、淋巴结转移和组织学分级与LSCC患者的无病生存率(DFS)相关。此外,在多变量生存分析中,淋巴结转移和低AGR对于OS和DFS仍然是显著的。

原始出处:
Chen WZ, et al. Preoperative albumin/globulin ratio has predictive value for patients with laryngeal squamous cell carcinoma. Oncotarget. 2017 Jul 18;8(29):48240-48247. doi: 10.18632/oncotarget.18443.

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    2018-03-28 仁医06
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encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Jan 16 01:22:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634734, encodeId=56dc1634e340b, content=<a href='/topic/show?id=864e4013957' target=_blank style='color:#2F92EE;'>#喉鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40139, encryptionId=864e4013957, topicName=喉鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d65b22270140, createdName=12498474m37暂无昵称, createdTime=Tue Sep 05 14:22:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238059, encodeId=7eb6238059be, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 28 18:27:01 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236924, encodeId=9769236924af, content=感谢小编为williamhill asia 准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:14:27 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304602, encodeId=7cef1304602a0, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Aug 25 07:22:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236841, encodeId=ba8623684169, content=可是为什么AGR会和预后相关呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220122/79536f724aeb457b92686dad2f67da53/e68df6215dc6452e9e90c0a6328717aa.jpeg, createdBy=775c1662187, createdName=悬光, createdTime=Fri Aug 25 01:18:19 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236660, encodeId=1a8523666050, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Aug 24 12:37:11 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2018-01-16 xzw113
  5. 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content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Aug 25 07:22:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236841, encodeId=ba8623684169, content=可是为什么AGR会和预后相关呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220122/79536f724aeb457b92686dad2f67da53/e68df6215dc6452e9e90c0a6328717aa.jpeg, createdBy=775c1662187, createdName=悬光, createdTime=Fri Aug 25 01:18:19 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236660, encodeId=1a8523666050, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Aug 24 12:37:11 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
  6. 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encryptionId=5a426866eae, topicName=球蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2317301, createdName=xzw113, createdTime=Tue Jan 16 01:22:00 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1634734, encodeId=56dc1634e340b, content=<a href='/topic/show?id=864e4013957' target=_blank style='color:#2F92EE;'>#喉鳞状细胞癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40139, encryptionId=864e4013957, topicName=喉鳞状细胞癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d65b22270140, createdName=12498474m37暂无昵称, createdTime=Tue Sep 05 14:22:00 CST 2017, time=2017-09-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238059, encodeId=7eb6238059be, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 28 18:27:01 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236924, encodeId=9769236924af, content=感谢小编为williamhill asia 准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:14:27 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304602, encodeId=7cef1304602a0, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Aug 25 07:22:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236841, encodeId=ba8623684169, content=可是为什么AGR会和预后相关呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220122/79536f724aeb457b92686dad2f67da53/e68df6215dc6452e9e90c0a6328717aa.jpeg, createdBy=775c1662187, createdName=悬光, createdTime=Fri Aug 25 01:18:19 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236660, encodeId=1a8523666050, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Aug 24 12:37:11 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2017-08-28 虈亣靌

    内容丰富.值得学习

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 28 18:27:01 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236924, encodeId=9769236924af, content=感谢小编为williamhill asia 准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:14:27 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304602, encodeId=7cef1304602a0, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Aug 25 07:22:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236841, encodeId=ba8623684169, content=可是为什么AGR会和预后相关呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220122/79536f724aeb457b92686dad2f67da53/e68df6215dc6452e9e90c0a6328717aa.jpeg, createdBy=775c1662187, createdName=悬光, createdTime=Fri Aug 25 01:18:19 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236660, encodeId=1a8523666050, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Aug 24 12:37:11 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2017-08-25 ylzr123

    感谢小编为williamhill asia 准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Aug 28 18:27:01 CST 2017, time=2017-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236924, encodeId=9769236924af, content=感谢小编为williamhill asia 准备了如此丰盛的精神大餐.同时也向作者致谢!认真学习了.点赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Aug 25 08:14:27 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1304602, encodeId=7cef1304602a0, content=<a href='/topic/show?id=cd37e1767b5' target=_blank style='color:#2F92EE;'>#白蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71767, encryptionId=cd37e1767b5, topicName=白蛋白)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25d7319, createdName=珙桐, createdTime=Fri Aug 25 07:22:00 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236841, encodeId=ba8623684169, content=可是为什么AGR会和预后相关呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220122/79536f724aeb457b92686dad2f67da53/e68df6215dc6452e9e90c0a6328717aa.jpeg, createdBy=775c1662187, createdName=悬光, createdTime=Fri Aug 25 01:18:19 CST 2017, time=2017-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236660, encodeId=1a8523666050, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Thu Aug 24 12:37:11 CST 2017, time=2017-08-24, status=1, ipAttribution=)]
    2017-08-25 珙桐
  9. 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    2017-08-25 悬光

    可是为什么AGR会和预后相关呢?

    0

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    2017-08-24 龙胆草

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