Clin Immunol:过敏性鼻炎患者对屋尘螨增加的先天2型免疫响应

2017-09-30 AlexYang MedSci原创

2型先天淋巴样细胞(ILC2s)在起始和促进过敏免疫响应中是必要的成员。然而,研究人员在探究过程中发现了ILC2水平的过敏性鼻炎(AR)患者中的不一致性。最近,有研究人员调查了ILC2在屋尘螨(HDM)过敏性AR病人外周血中的水平,并且还调查了他们分泌2型细胞激素的能力。研究发现,ILC2s且具有ILC2表型特性的水平在HDM-AR病人中增加。AR病人的症状得分和IL-13的水平与HDM-AR病人

2型先天淋巴样细胞(ILC2s)在起始和促进过敏免疫响应中是必要的成员。然而,研究人员在探究过程中发现了ILC2水平的过敏性鼻炎(AR)患者中的不一致性。最近,有研究人员调查了ILC2在屋尘螨(HDM)过敏性AR病人外周血中的水平,并且还调查了他们分泌2型细胞激素的能力。研究发现,ILC2s且具有ILC2表型特性的水平在HDM-AR病人中增加。AR病人的症状得分和IL-13的水平与HDM-AR病人中的ILC2s有着正相关关系。另外,上皮细胞因子的刺激诱导了IL-5和IL-13在AR病人PBMCs中剧烈的产生。研究人员还成功的从AR病人中分离了ILC2s,并且鉴定了他们产生2型细胞激素的能力。研究还发现了ILC2s的数目在HDM-AR病人中增加了并且在上皮细胞激素存在的情况下,ILC2s产生了大量的TH2细胞激素,这也表明了ILC2在AR病人中的重要角色。原始出处:Zhong H, Fan XL, Yu QN et al. Increased innate type 2 immune response in house dust mite-allergic patients with a

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    2017-10-03 半夏微凉

    学习了谢谢分享

    0

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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-03 chunjianf

    学习了.谢谢分享

    0

  5. 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    2017-10-03 明天会更好!

    谢谢分享.学习了

    0

  6. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1944050, encodeId=9e7f19440506b, content=<a href='/topic/show?id=f48228993d0' target=_blank style='color:#2F92EE;'>#免疫响应#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28993, encryptionId=f48228993d0, topicName=免疫响应)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82369, createdName=jiekemin, createdTime=Wed Nov 22 02:28:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046888, encodeId=aca4204688820, content=<a href='/topic/show?id=6f5294036b1' target=_blank style='color:#2F92EE;'>#过敏性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94036, encryptionId=6f5294036b1, topicName=过敏性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a8e213, 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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Oct 01 08:36:45 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249325, encodeId=9286249325cb, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Oct 01 08:18:11 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249316, encodeId=e24f249316e6, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 执着追梦

    学习.谢谢分享

    0

  9. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 明月清辉

    谢谢分享.学习了

    0

  10. 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likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Sun Oct 01 08:36:45 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249325, encodeId=9286249325cb, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Oct 01 08:18:11 CST 2017, time=2017-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=249316, encodeId=e24f249316e6, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Oct 01 08:14:45 CST 2017, time=2017-10-01, status=1, ipAttribution=)]
    2017-10-01 Y—xianghai

    学习了新知识

    0

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最近,有研究人员进行了旨在比较真实临床背景下,舌下免疫疗法(SLIT)和皮下注射免疫疗法(SCIT)病人生活质量(QOL)变化情况。SLIT是建立作为SCIT之外,可行的且可选择的治疗过敏性鼻炎的一种治疗方法。尽管比较试验越来越多,但是很少有研究比较这两种治疗方法对QOL结果的影响比较。该研究是一个前瞻性的、单中心的研究。研究包括了105名因空气传播过敏原而过敏的病人,且经历了免疫治疗。40名参与

秋季哮喘高发,上下气道共治

一阵秋雨一阵凉,由于秋季空气逐渐变冷、昼夜温差大,再伴随过敏原、呼吸道病毒开始活跃等问题,哮喘的发病率明显增多。也许很多人没有注意到,过敏性鼻炎和哮喘很多时候存在“共生”关系,哮喘会合并过敏性鼻炎,而反复的严重过敏性鼻炎发作以后,病人慢慢会出现咳嗽和气喘。专家指出,哮喘和过敏性鼻炎是“同一气道,同一疾病”,有鼻炎的哮喘病人,两个病要联合治疗。而对于家长关心的激素长期使用是否会上瘾,什么时候才能

Int Immunopharmacol:黄芩新素能够减轻卵清蛋白诱导的过敏性鼻炎症状

过敏性鼻炎是一种常见的多样化的慢性上呼吸道障碍疾病,并且是一种lgE调控的炎症,可以通过一种或者多种鼻部症状,如打喷嚏、鼻痒、流鼻涕、鼻液溢、后鼻排水和鼻塞来进行鉴定。最近,有研究人员调查了黄芩新素 II (SCF II )对上呼吸道炎症、Th2细胞激素和在卵清蛋白(OVA)诱导的过敏性鼻炎(AR)小鼠模型体内NF-κB 信号的影响。研究发现,OVA诱导的AR小鼠鼻部症状、嗜酸细胞和肥大细胞渗透到

Mediators Inflamm:IL-25参与了屋尘螨敏感的过敏性鼻炎的发展

屋尘螨是一种常见的过敏,当屋尘螨(HDM)附着到黏膜上的时候,它可以刺激先天免疫。然而,IL-25在HDM诱导的鼻过敏性炎症中的精确角色仍旧不清楚。因此,最近有研究人员调查了屋尘螨敏感的过敏性鼻炎(AR)中的IL-25的作用。为了确认IL-25在人类鼻上皮细胞(HNECs)的产生,研究人员刺激了HNECs,并利用免疫组化技术和定量反转录PCR技术评估了IL-25在对照组、非AR病人(NAR)和HD

Rhinology:儿童和成年人过敏性鼻炎的相似性和差异

过敏性鼻炎(AR)在世界范围内是一种高度流行的疾病。尽管有许多关于AR的研究,但是在比较儿童和成年人AR群体方面还没有研究。最近,有研究人员进行了旨在比较儿童群体和成年人群体AR特性的研究。研究的AR群体(儿童和成年人)来自西班牙,并通过代表性的观察、多中心研究来对两个群体进行比较。另外,研究人员根据经典的(变应原接触)、原始的(o-ARIA)和修正的(m-ARIA)ARIA标准对AR进行了分类鉴

Rhinology:过敏性鼻炎和非过敏性鼻炎病人鼻甲成形术后气流和症状结果分析

下鼻甲成形术被用来减轻医疗上难治性鼻阻塞。然而,阻塞的本质原因在过敏性鼻炎(AR)和非过敏性鼻炎(NAR)病人中是不同的。最近,有研究人员比较了术后AR病人和NAR病人治疗结果。研究人员设计的研究为案例-对照研究。参与的病人因鼻阻塞经历了鼻甲手术,其中包括具有鼻中隔成形术手术和不具有鼻中隔成形术手术。病人报道的结果有:鼻阻塞情况、全鼻功能(GNF)和鼻炎的鼻腔鼻窦结局测试(SNOT-22)、面部症