Hypertension:血浆瘦素水平和血压进展之间的关系

2021-03-12 MedSci原创 MedSci原创

血浆瘦素浓度可能有助于识别高危人群,在未来的研究中可以将其作为高血压预防和治疗策略的靶点。

在黑人中关于血浆瘦素水平与血压(BP)进展之间关系的资料很少。

近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估黑人群体血浆瘦素水平与血压升高和高血压发生率之间的关系。

研究人员分析了1190名杰克逊心脏研究的参与者,他们在2000-2004年基线时没有高血压,并接受了1次以上随访(2005-2008年或2009-2013年)。研究人员使用修正泊松回归来得到血压升高和高血压(血压≥130/80mmHg或使用抗高血压药物)的多变量校正风险比(RRs)和95%CI。

在1190名参与者中,64.1%为女性(n=763),平均年龄为48岁(SD为12)。在中位7年的随访期间,71.3%的参与者血压升高(n=848), 64.6%的参与者发展为高血压患者(n=769)。调整混杂因素后,血浆瘦素水平对数值每增加一个SD值,与血压升高(RR为1.10 [95%CI为1.03-1.18],P=0.007)和高血压发生(RR为1.14 [95%CI为1.05-1.23],P=0.002)更高的风险相关。与瘦素水平最低的四分位数组相比,瘦素水平最高的四分位数组患者发生血压升高(RR为1.27 [95%CI为1.05-1.54],趋势P=0.007)和发生高血压(RR为1.32 [95%CI为1.07-1.64],趋势P=0.010)的风险显著增加。

由此可见,血浆瘦素浓度可能有助于识别高危人群,在未来的研究中可以将其作为高血压预防和治疗策略的靶点

原始出处:

Arnaud D. Kaze.et al.Plasma Leptin and Blood Pressure Progression in Blacks The Jackson Heart Study.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.16174

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    2021-04-18 feather89
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    2021-03-14 sodoo
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    2021-03-12 wxl882001

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