Development：生物钟竟然能够影响癌症进程！你真的会睡觉吗？

2018-05-10 heidi 转化医学网

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四川大学华西医院研究员/ 助理研究员

导读乳腺癌是妇女最常见的恶性肿瘤之一，目前发病年龄提前，发病率呈上升趋势。科学家通过对患者的基因研究发现，有2种直接与遗传性乳腺癌相关的基因，分别是BRCA1和BRCA2。

导读

乳腺癌是妇女最常见的恶性肿瘤之一，目前发病年龄提前，发病率呈上升趋势。科学家通过对患者的基因研究发现，有2种直接与遗传性乳腺癌相关的基因，分别是BRCA1和BRCA2。

近期，德州农工大学的研究人员已经发现了另一种可能对乳腺癌有影响的基因——Per2，即调节人体生物节奏的核心基因。

德州农工大学的兽医医学与生物医学科学(CVM)韦斯顿波特教授和他的团队发现,第二时期(Per2),监管机制在每个细胞的外围时钟,扮演了一个至关重要的功能，在哺乳动物乳腺肿瘤发展和抑制,Per2是影响乳腺肿瘤发展的重要基因。

这项发表在科学期刊《Development》上，williamhill asia 大脑中调节机体生物节奏的核心基因Per2——在肿瘤发展进程中发挥着重要作用。

昼夜节律是由大脑前下丘脑的视交叉上核(SCN)控制。除了协调williamhill asia 的睡眠模式，SCN还协调williamhill asia 身体的其他外围时钟，每天24小时运行着。当你早晨醒来，看到光，光线进入大脑，就会触发调节生物昼夜节奏调节过程的分子机制。

波特的团队对Per2进行了评估。Per2提供了“负面反馈”，也就是对生物昼夜节奏调节过程的平衡。消极和积极的反馈机制一直处于平衡状态，上下波动。Per2，它会抑制另一种叫做BMAL或时钟的基因，在维持和调节生物节奏发挥了重要作用。

研究发现，Per2在哺乳动物乳腺发育过程中起着至关重要的作用，特别是在Per2细胞分化和识别。研究发现小鼠的生物节律基因Per2可能通过诱导肿瘤细胞凋亡来实现对肿瘤细胞的生长抑制作用。

研究发现有些腺体有一种williamhill asia 称之为双强表型的东西;他们实际上是癌症的一半，它们已经具备了你在前恶性细胞中所能看到的许多特征。研究与此相关的机制，发现与丢失Per2相关的干细胞标记更显著，这是更具侵袭性的癌症的特征。这进一步证实了Per2是一种与细胞身份相关的肿瘤抑制基因。

除了对乳腺发育的破坏外，波特在移植研究中也发现了同样的缺陷，表明它是Per2，而不仅仅是中央时钟本身，这是导致发育腺中乳腺导管生长缺失的原因。研究表明，Per2水平下降和某些类型的乳腺癌之间存在关系。

通过对控制昼夜节律的分子机制的研究，让williamhill asia 发现了和癌症存在的关系，Per2基因可以达到抑制肿瘤细胞的生长，诱导肿瘤细胞凋亡的作用。而此项研究发现，经常从事夜班工作的女性引起的不规律生物节奏周期，会显著增高患乳腺癌的风险。

原始出处：

Cole M. McQueen, et al.PER2 regulation of mammary gland development.Development 2018 145: dev157966 doi: 10.1242/dev.157966 Published 14 March 2018

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2018-05-13 wzb521zf

一起学习学习

78 0
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2018-05-12 tsing_hit

#睡觉#

48 0
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2018-05-12 易水河

不容易呀

73 0
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2018-05-11 龙胆草

学习谢谢分享

70 0
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2018-05-11 天地飞扬

了解一下.谢谢分享!

60 0
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2018-05-11 张新亮1853311252142e2fm

好文献学习了

46 0
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2018-05-11 chunjianf

学习了.谢谢分享

51 0
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2018-05-11 三生有幸9135

学习一下谢谢分享

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