ATVB:Takotsubo综合征患者心室内血栓形成和栓塞情况

2019-11-26 xing.T MedSci原创

由此可见,3.3%的急性期TTS患者发生心室内血栓和栓塞。一个简单的风险评分(包含与心室内血栓形成和栓塞相关的临床参数)可以识别风险增加的患者。

Takotsubo综合征(TTS)的特征是急性左心功能不全,可导致心室内血栓和栓塞。尽管如此,血栓形成和栓塞事件的患病率以及对TTS患者预后的临床影响尚不清楚。近日,心血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,这项研究旨在调查有无心室内血栓或栓塞的患者临床特征和结局。此外,明确与血栓形成和栓塞相关的因素,以及死亡率的预测因素。

根据心室内无血栓或栓塞发生的情况,将在澳大利亚、欧洲和美国28个中心的国际Takotsubo Registry登记中心的TTS患者一分为二。心室内血栓或栓塞的患者定义为ThrombEmb组。

在1676名TTS患者中,有56名(3.3%)患者在TTS诊断后出现心室内血栓和/或栓塞(中位时间间隔为2.0天[范围为0-38天])。ThrombEmb组患者具有不同的临床特征,包括较低的左心室射血分数,较高的心尖型患病率,肌钙蛋白和炎性标志物水平升高以及较高的血管疾病患病率。在偏倚减少的惩罚性Logistic回归模型中,心尖类型、左心室射血分数≤30%,既往血管疾病和入院时白细胞计数>10×103细胞/μL是血栓形成和栓塞的独立预测因子。

由此可见,3.3%的急性期TTS患者发生心室内血栓和栓塞。一个简单的风险评分(包含与心室内血栓形成和栓塞相关的临床参数)可以识别风险增加的患者。 

原始出处:

Katharina J. Ding,et al.Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome Insights From the International Takotsubo Registry.ATVB.2019.https://www.ahajournals.org/doi/10.1161/ATVBAHA.119.313491

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    2020-09-15 gongliu
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    2019-11-28 axin015
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    2019-11-27 14794e5bm67(暂无昵称)

    研究很前沿,受益良多

    0

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    2019-11-27 飛歌

    学习了很有用不错

    0

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    2019-11-26 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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