JCEM:糖尿病、脑梗塞、认知和小血管疾病

2020-11-11 MedSci原创 MedSci原创

小血管疾病是糖尿病和VBI之间许多关系的特征。但是,还需要其他因素来解开糖尿病与认知障碍之间的关系。

糖尿病是脑血管疾病和认知障碍的危险因素,但其解剖基础尚未明确。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章。加拿大健康心智联盟(CAHHM)收集了大脑和颈动脉核磁共振成像(MRI)结果。脑部MRI可以识别脑梗塞(BI)、腔隙性BI、高白质高信号(WMH)、血管性脑损伤(VBI-BI或高WMH)和小血管VBI(腔壁BI或高WMH)。颈动脉MRI估计颈动脉壁体积,这是对亚临床动脉粥样硬化的一个衡量指标。认知分数是根据每个领域的平均分数标准化的,认知障碍通过一个或两个测试分数低于该领域的平均分数的标准差≤1的标准来识别。

7733名参与者中495名(6.4%)参与者患有糖尿病,其中388名正在服用糖尿病药物。经过年龄和性别调整后,糖尿病与BI(OR为1.53,95%CI为1.05,2.24)、VBI(OR为1.64,95%CI为1.26,2.13)、小血管VBI(OR为1.67,95%CI为1.28,2.19)和认知障碍(OR为1.47,95%CI为1.20,1.80)独立相关。调整脑血管疾病危险因素和非腔隙性梗死后,糖尿病与小血管VBI之间的关联仍然存在(OR为1.52,95%CI为1.15,2.01),而对小血管VBI进行调整后,其与认知损伤之间的关系仍然存在(OR为1.27, 95%CI为1.03,1.56)。

由此可见,小血管疾病是糖尿病和VBI之间许多关系的特征。但是,还需要其他因素来解开糖尿病与认知障碍之间的关系。

原始出处:

Hertzel C Gerstein.et al.Diabetes, Brain Infarcts, Cognition and Small Vessels in the Canadian Alliance for Healthy Hearts and Minds Study.JCEM.2020.https://doi.org/10.1210/clinem/dgaa815

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    2021-06-20 achengzhao
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    2020-11-22 smallant2015
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    2020-11-13 karmond
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    2020-11-11 misszhang

    谢谢MedSci提供最新的威廉亚洲官网

    0

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