Stroke:一类被忽视的高危人群-P波完全消失的非房颤患者

2021-03-07 MedSci原创 MedSci原创

CPWD反映了广泛的心房电活动沉默和明显的心房机械功能受损。它与血栓栓塞密切相关,并提出了CPWD-心房瘫痪-脑卒中的临床三联征。对于此类患者应推荐进行抗凝治疗。

无房颤个体出现P波完全消失(CPWD)是一种少见的临床现象。近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在探究CPWD与血栓栓塞之间的关系。

在2007年7月至2018年12月期间,研究人员从中国4个中心招募了经体表心电图和24小时动态心电图记录的CPWD患者。所有被招募的患者都接受了经食管超声心动图或心脏计算机断层扫描来筛查有无心房血栓。

研究人员采用电生理研究(EPS)和三维电解剖图来评价心房电活动和瘢痕,并采用多通道心脏显像技术评价心脏结构和功能。

该研究纳入了23例连续就诊的患者(8名男性;平均年龄为48.5±14.7岁)。只有3例患者表现出心房电活动完全沉默且心房电信号未被捕获。13例接受有创心房内膜图检查的患者显示大面积瘢痕。二尖瓣流入的脉波多普勒检查发现18例A波消失患者和5例A波减弱患者。三尖瓣流入多普勒超声发现19例A波消失患者,14例A波减弱患者。招募时,8例患者有脑卒中病史,3例患者有心房血栓。所有患者均使用华法林治疗。中位随访42.0个月,2例患者因停用华法林而发生大面积缺血性卒中。

由此可见,CPWD反映了广泛的心房电活动沉默和明显的心房机械功能受损。它与血栓栓塞密切相关,并提出了CPWD-心房瘫痪-脑卒中的临床三联征。对于此类患者应推荐进行抗凝治疗。

原始出处:

Hailei Liu.et al.Nonatrial Fibrillation Patients With Complete P Wave Disappearance An Overlooked Population With High Stroke Risk.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031889

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1675087, encodeId=0bbe16e508751, content=<a href='/topic/show?id=7d321022504e' target=_blank style='color:#2F92EE;'>#高危人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102250, encryptionId=7d321022504e, topicName=高危人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95727161035, createdName=Smile2689, createdTime=Sat Jan 15 20:55:06 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614589, encodeId=67cd161458905, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Tue Mar 09 07:55:06 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031360, encodeId=e47e1031360a6, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sun Mar 07 19:55:06 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946213, encodeId=41cf9462133a, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Mar 07 17:44:31 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946189, encodeId=727c946189c4, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Mar 07 16:59:15 CST 2021, time=2021-03-07, status=1, ipAttribution=)]
    2021-03-07 心介

    房颤,临床上碰到很多哦

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1675087, encodeId=0bbe16e508751, content=<a href='/topic/show?id=7d321022504e' target=_blank style='color:#2F92EE;'>#高危人群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102250, encryptionId=7d321022504e, topicName=高危人群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95727161035, createdName=Smile2689, createdTime=Sat Jan 15 20:55:06 CST 2022, time=2022-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614589, encodeId=67cd161458905, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Tue Mar 09 07:55:06 CST 2021, time=2021-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031360, encodeId=e47e1031360a6, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Sun Mar 07 19:55:06 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946213, encodeId=41cf9462133a, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sun Mar 07 17:44:31 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=946189, encodeId=727c946189c4, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Mar 07 16:59:15 CST 2021, time=2021-03-07, status=1, ipAttribution=)]
    2021-03-07 jyzxjiangqin

    好文章!

    0

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    2021-03-07 医鸣惊人

    认真学习了

    0

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