Br J Cancer:个子高,这些癌症风险也高!

2020-09-20 xiaozeng MedSci原创

身高虽然易于测量,但却是一个复杂的表型,由多种生物学和社会学因素所决定。既往研究显示,身高与许多慢性疾病相关,包括心血管疾病和癌症。前瞻性队列研究显示,身高与多个部位癌症的高发病风险密切相关。

身高虽然易于测量,但却是一个复杂的表型,由多种生物学和社会学因素所决定。既往研究显示,身高与许多慢性疾病相关,包括血管疾病和癌症。前瞻性队列研究显示,身高与多个部位癌症的高发病风险密切相关。

目前尚不清楚身高与癌症的相关性是否由胰岛素样生长因子的不同所引起的。因此,该研究旨在分析身高与24个部位特异性癌症之间的性别特异性关联,并评估该关联是否与IGF-1相关。


研究人员共募集了来自英国生物样品库瞻性队列研究中的414,923名参与者。通过比例风险(Cox)回归模型分析身高(每增加5厘米)与24个部位癌症的发病率和死亡率之间的关联型。该研究的随访中位时间为6年。

男性身高与癌症风险相关性

研究人员发现,男性身高与全因性癌症以及五个部位(肺、淋巴、白血病、非霍奇金淋巴瘤和黑色素瘤)的发病风险呈正相关。

女性身高与癌症风险相关性

在女性中,身高与全因性癌症、乳腺癌、黑色素瘤、淋巴瘤和非霍奇金淋巴瘤相关。

男女性身高与癌症风险相关性对比

对于全因性癌症的发病率,女性相比男性相关性更高。而身高与癌症的关联强度不因IGF-1浓度而异。


综上,该研究结果显示,成人身高与某些部位癌症的发病风险相关。其中的一部分关联性与性别相关。目前并无强有力的证据证明IGF-1与关联性的关系。


原始出处:

Parra-Soto, S., Ho, F.K., Pell, J.P. et al. Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?. Br J Cancer (14 September 2020).

 

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    2021-04-30 MedSciZeng

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    2021-04-30 MedSciZeng

    Br J Cancer

    0

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    2020-09-22 12346c4dm64暂无昵称

    论基因重要性😂

    0

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    2020-09-20 Nebula-Qin

    get到了个子矮的一个新优点,手动哭笑脸

    0

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已有临床试验证实,达拉非尼和曲美替尼(D+T)新辅助治疗在可手术切除的临床Ⅲ期携带BRAFV600E/K突变黑色素瘤患者中的安全性和有效性。尽管pCR患者相较于non-pCR患者表现出更好的无复发生存

停止日光浴!1970年以来皮肤癌死亡人数激增70%

每两年被晒伤一次的人患皮肤癌的风险升高三倍。

Nature: 推波助澜,淋巴系统可保护瘤细胞免于铁死亡,促进癌细胞转移

该研究显示淋巴中的黑素瘤细胞比血液中的黑素瘤细胞经历较少的氧化应激并形成更多的转移。