Br J Surg:体脂构成对胰十二指肠切除术后结局的影响

2016-02-17 Mechront 译 MedSci原创

本研究的目的是评估身体成分对行胰十二指肠切除术的癌症患者预后的影响。人体参数包括全腹肌肉面积(TAMA)和内脏脂肪面积(VFA),由CT进行评估。通过数据库获取围手术期变量和术后结局(死亡率或术后胰瘘)的相关信息。使用优化分层来确定人体测量的最佳临界值。通过多因素分析获得60天死亡率和胰瘘的独立预测因子。该研究共纳入了202名患者,132名(65.3%)分类为肌肉减少,发生了12例(5.9%)术后

本研究的目的是评估身体组份对行胰十二指肠切除术的癌症患者预后的影响。

人体参数包括全腹肌肉面积(TAMA)和内脏脂肪面积(VFA),由CT进行评估。通过数据库获取围手术期变量和术后结局(死亡率或术后胰瘘)的相关信息。使用优化分层来确定人体测量的最佳临界值。通过多因素分析获得60天死亡率和胰瘘的独立预测因子。

该研究共纳入了202名患者,132名(65.3%)分类为肌肉减少,发生了12例(5.9%)术后死亡,有40名(19.8%)患者出现了主要的并发症,48名(23.8%)患者出现了术后胰瘘。多因素分析显示,VFA/TAMA超过3.2,美国麻醉医师协会Ⅲ级是预测死亡率最强的因子(OR=6.67和6.10;P值均<0.001)。经历了术后主要并发症的患者中,幸存者与非幸存者相比,有更低的VFA/TAMA比率(P = 0·017)。VFA是术后胰瘘的独立预测因子(最佳阈值 167 cm2 : OR 4.05; P < 0.001)。

研究数据表明,进行胰十二指肠切除术的癌症患者中肌肉减少很常见。内脏肥胖和肌肉减少是术后死亡的最好预测因子,VFA是术后胰瘘的独立预测因子。

原始出处:

Pecorelli N, Carrara G,et al.Effect of sarcopenia and visceral obesity on mortality and pancreatic fistula following pancreatic cancer surgery.Br J Surg. 2016 Jan 18. doi: 10.1002/bjs.10063.


版权声明:
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于williamhill asia 医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章,或“williamhill asia 号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系,williamhill asia 将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1876760, encodeId=70d118e6760bf, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Jan 02 04:19:00 CST 2017, time=2017-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900666, encodeId=0e141900666fa, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Mon Jun 27 16:19:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544041, encodeId=3554154404155, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Feb 19 12:19:00 CST 2016, time=2016-02-19, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1876760, encodeId=70d118e6760bf, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Jan 02 04:19:00 CST 2017, time=2017-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900666, encodeId=0e141900666fa, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Mon Jun 27 16:19:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544041, encodeId=3554154404155, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Feb 19 12:19:00 CST 2016, time=2016-02-19, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1876760, encodeId=70d118e6760bf, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Mon Jan 02 04:19:00 CST 2017, time=2017-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900666, encodeId=0e141900666fa, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Mon Jun 27 16:19:00 CST 2016, time=2016-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544041, encodeId=3554154404155, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Fri Feb 19 12:19:00 CST 2016, time=2016-02-19, status=1, ipAttribution=)]
    2016-02-19 heli0118