JAMA Netw Open:中山大学研究:母乳喂养可保护空气污染时的儿童肺功能

2019-05-31 朱朱 中国循环杂志

5月24日,中山大学公共卫生学院董光辉教授研究团队在JAMA网络开放子刊发表的一项横断面研究提示,对于暴露在污染空气中的中国儿童来说,母乳喂养可降低空气污染导致的肺功能受损风险,12岁以下儿童获益尤其明显。

5月24日,中山大学公共卫生学院董光辉教授研究团队在JAMA网络开放子刊发表的一项横断面研究提示,对于暴露在污染空气中的中国儿童来说,母乳喂养可降低空气污染导致的肺功能受损风险,12岁以下儿童获益尤其明显。

研究显示,校正年龄、性别和其他潜在混淆因素后,空气中PM1、 PM2.5、PM10浓度每升高1个四分位数间距,曾接受母乳喂养的儿童中肺功能受损(用力肺活量<85%)的风险分别增加20%、26%、46%,其中小学生肺功能受损风险较高,分别增加89%、50%、52%。

相应地,在未接受母乳喂养的儿童中,肺功能受损分别增加171%、127%、93%,其中小学生肺功能受损风险分别增加5.43倍、2.83倍、1.61倍。

研究者发现,随着年龄的增长,母乳喂养对肺功能的有益作用可能会降低。在曾接受母乳喂养的儿童中,年龄<12岁者肺功能受损的风险相对较低。

线性回归分析进一步表明,在未接受母乳喂养的儿童中,空气污染暴露会导致肺功能比曾接受母乳喂养者更差,包括用力肺活量和第一秒用力呼气量。

关于母乳喂养与空气污染和肺功能受损相关的潜在机制,研究者表示,目前尚不明确,可能与母乳促进肺部免疫建立以及抗感染、抗氧化、抗炎等作用有关。

该研究从中国7个城市的62所中小学纳入6740名儿童,其平均年龄为11.6岁,男女差不多各一半。其中,70.5%的儿童曾接受母乳喂养。

在这些儿童中,用最大呼气流量<75%评估的肺功能受损患病率最低,为6.8%,用用力肺活量<85%评估的肺功能受损患病率最高,为11.3%。

原始出处:Zhang C1, Guo Y2, Xiao X1, et al. Association of Breastfeeding and Air Pollution Exposure With Lung Function in Chinese Children. JAMA Netw Open. 2019 May 3;

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    2019-09-29 canlab
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    2020-02-25 feather89
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    2019-06-02 villahu
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