Ann Oncol:食管鳞癌精准化放疗效果与手术相似

2012-08-16 君亭 医学论坛网

     《肿瘤学年鉴》(Ann Oncol)近期发表的一项研究表明,食管鳞状细胞癌患者接受精准化放疗(CRT)的长期生存状况与手术相似;尚需大型研究探讨CRT对淋巴结阳性患者的疗效。   该研究的目的是在可切除食管癌患者中对比精准CRT和标准食管切除术后患者的5年生存预后。   从2000年7月至2004年12月,共有81例可切除中低位胸段食管鳞状细胞癌患者随机接受食管切除术或精准CRT。主要终

  
  《肿瘤学年鉴》(Ann Oncol)近期发表的一项研究表明,食管鳞状细胞癌患者接受精准化放疗(CRT)的长期生存状况与手术相似;尚需大型研究探讨CRT对淋巴结阳性患者的疗效。
  该研究的目的是在可切除食管癌患者中对比精准CRT和标准食管切除术后患者的5年生存预后。
  从2000年7月至2004年12月,共有81例可切除中低位胸段食管鳞状细胞癌患者随机接受食管切除术或精准CRT。主要终点是总生存,次要终点包括无病生存和死亡率。
  结果显示, 45例患者接受了食管切除术,36例患者接受了精准CRT。CRT组5年总生存优于手术组,但差异未达到统计学显著性(29.4% 对 50%,P=0.147)。CRT组5年无病生存改善趋于显著(P=0.068),这种趋势在淋巴结阳性患者中更为明显(P=0.017)。疾病分期和白蛋白水平是死亡率和无病生存的显著预测因素。
  

相关链接:A. Y. B. Teoh1,P. W. Y. Chiu,W. K. Yeung,S. Y. W. Liu,S. K. H. Wong and E. K. W. Ng1,Long-term survival outcomes after definitive chemoradiation versus surgery in patients with resectable squamous carcinoma of the esophagus: results from a randomized controlled trial.Ann Oncol,

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    2013-01-01 minlingfeng
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    2012-08-18 zhouqu_8
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