Sci Rep:高风险人乳头瘤病毒与乳腺癌

2017-02-28 MedSci MedSci原创

人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中。评估乳腺癌(BC)中HPV的存在产生了相当大的争议。到目前为止,大多数研究集中在BC中存在病毒DNA;然而证明HPV在BC侵袭中的作用仍存在巨大的不足。关于此的一些相关研究已经在数个国家中进行,但尚未有关于BC高风险(HR)的HPV的存在和生物活性在英国进行研究。近期,一项发表在杂志Sci Rep上的研究通过使用PCR和Sanger测序方法

人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中。


评估乳腺癌(BC)中HPV的存在产生了相当大的争议。到目前为止,大多数研究集中在BC中存在病毒DNA;然而证明HPV在BC侵袭中的作用仍存在巨大的不足。

关于此的一些相关研究已经在数个国家中进行,但尚未有关于BC高风险(HR)的HPV的存在和生物活性在英国进行研究。

近期,一项发表在杂志Sci Rep上的研究通过使用PCR和Sanger测序方法筛选来自英国患者的共110个新鲜乳腺组织标本中存在的12种HR-HPV类型的DNA。使用蛋白质印迹和斑点印迹筛选HPV-DNA阳性的样品的病毒癌蛋白表达。

此项研究数据显示在42%的乳腺组织中存在HR-HPV,其中病毒活性仅在一些侵袭性癌中被证实(5/26)。这一发现表明,病毒癌蛋白在侵袭性病例中的选择性表达可能提供了HR-HPVs在一些类型BC的发展中的作用。

原始出处:
Salman NA, Davies G, et al. Association of High Risk Human Papillomavirus and Breast cancer: A UK based Study. Sci Rep. 2017 Feb 27;7:43591. doi: 10.1038/srep43591.

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    2017-04-06 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

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    2017-04-02 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-03-23 jyzxjiangqin

    高风险人乳头瘤病毒与乳腺癌。

    0

  5. 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  6. 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    2017-03-01 1e1a50a1m36(暂无匿称)

    人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中

    0

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07:47:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443479, encodeId=588b14434e9f6, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Thu Mar 02 11:56:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178282, encodeId=28281e828270, content=人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-03-01 cuiyejia

    谢谢了啊

    0

  8. 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07:47:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443479, encodeId=588b14434e9f6, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Thu Mar 02 11:56:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178282, encodeId=28281e828270, content=人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 1e15b6fem30(暂无匿称)

    很好的学习资料,谢谢。

    0

  9. 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07:47:00 CST 2017, time=2017-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1443479, encodeId=588b14434e9f6, content=<a href='/topic/show?id=4a65246327c' target=_blank style='color:#2F92EE;'>#人乳头瘤病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24632, encryptionId=4a65246327c, topicName=人乳头瘤病毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5fb15077773, createdName=ms3297076796458174, createdTime=Thu Mar 02 11:56:00 CST 2017, time=2017-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178282, encodeId=28281e828270, content=人乳头瘤病毒(HPV)的感染已经牵涉在多种癌症的病因学中, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuF63NQckT5BOaic1el7cRelbpr859YXtZQHQSaWnqZCRPOZzDBcjsBNx7AFefLHh1UvMPS4kPP0BG/0, createdBy=47831990981, createdName=1e1a50a1m36(暂无匿称), createdTime=Wed Mar 01 06:18:02 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178272, encodeId=d3fd1e827218, content=谢谢了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Wed Mar 01 05:21:27 CST 2017, time=2017-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178253, encodeId=f46f1e8253bc, content=很好的学习资料,谢谢。, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 䖝二

    我去-_-||

    0

  10. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161026/IMG58107C0F82E499574.jpg, createdBy=00e81970035, createdName=1e15b6fem30(暂无匿称), createdTime=Tue Feb 28 23:43:24 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178250, encodeId=ccc91e825035, content=我去-_-||, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Tue Feb 28 22:47:46 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=178243, encodeId=27d71e824343, content=学习了,谢谢作者分享!赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Feb 28 21:30:31 CST 2017, time=2017-02-28, status=1, ipAttribution=)]
    2017-02-28 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!赞一个

    0

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近日,北京东方略生物医药科技股份有限公司(ApolloBio)宣布与美国Inovio生物制药公司达成独家合作协议。ApolloBio将出资3500万美元获得Inovio旗下针对人乳头瘤病毒(HPV)的免疫治疗项目——VGX-3100在中国(包括台湾、香港和澳门地区)的研发和商业化权利。VGX-3100是全球首个针对HPV癌前病变的治疗性疫苗,处于临床Ⅲ期,其适应症包括HPV感染引发的癌前病变、异常

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郎景和院士谈宫颈癌防治

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