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Radiology：锰与钆的对决--谁才是MR对比剂王座的主人？

2017-12-30 shaosai MedSci原创

对比剂MRA锰
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本研究旨在比较锰磁共振（MR）对比剂Mn-PyC3A与钆MR对比剂Gd-DTPA的血管内强化效果，评价Mn-PyC3A的排泄、药物动力学参数和代谢，并将结果发表在Radiology上。

本研究旨在比较锰磁共振（MR）对比剂Mn-PyC3A与钆MR对比剂Gd-DTPA的血管内强化效果，评价Mn-PyC3A的排泄、药物动力学参数和代谢，并将结果发表在Radiology上。

本研究使用狒狒（东非狒狒，n=4）进行Mn-PyC3A和Gd-DTPA对比增强MR血管造影。在Mn-PyC3A注射后进行动态成像约60分钟来观察对比剂的分布和排泄。利用电感藕合等离子体质谱连续血清采样来定量锰和钆血浆清除率，利用高效液相层析评价Mn-PyC3A代谢。在注射Mn-PyC3A 或 Gd-DTPA9秒后，通过测量与肌肉的对比噪声比（CNRs）来定量腹主动脉、头臂干血管强化程度。用双指数动力学模型分析血浆药物动力学，并用配对T检验进行比较。

Mn-PyC3A 和Gd-DTPA主动脉与肌肉CNR分别为476 ± 77 、538 ± 120（P = .11），头臂干与肌肉的CNR分别为524 ± 55、518 ± 140(P = .95)。Mn-PyC3A经肾脏和肝胆系排泄，药物动力学与Gd-DTPA相似（AUC在0-30分钟之间分别为20.2 ± 3.1、17.0 ± 2.4，P = .23）。液相色谱法未显示Mn-PyC3A生物转化异常。

本研究表明，Mn-PyC3A能够产生与钆对比剂相似的强化效果，也行能够解决钆相关毒性及沉积的问题。

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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 31 09:13:56 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274066, encodeId=e7b32e4066dc, content=希望更少的副作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Dec 31 08:00:16 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274060, encodeId=aaa02e40609e, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2018-01-06 lou.minghong

    学习谢谢分享!

    0

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    2018-01-03 wl1122050

    不错的.临床在用吗?

    0

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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2018-01-02 chunjianf

    学习了.谢谢分享

    0

  4. 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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 31 09:13:56 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274066, encodeId=e7b32e4066dc, content=希望更少的副作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Dec 31 08:00:16 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274060, encodeId=aaa02e40609e, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2018-01-01 lofter

    学习了感谢分享

    0

  5. 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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 31 09:13:56 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274066, encodeId=e7b32e4066dc, content=希望更少的副作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Dec 31 08:00:16 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274060, encodeId=aaa02e40609e, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 hhh678

    henhao

    0

  6. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 明月清辉

    谢谢分享.学习了

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Sun Dec 31 10:46:13 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274112, encodeId=76c62e411222, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Dec 31 09:39:20 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274096, encodeId=52192e40966c, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Dec 31 09:13:56 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274066, encodeId=e7b32e4066dc, content=希望更少的副作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Sun Dec 31 08:00:16 CST 2017, time=2017-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274060, encodeId=aaa02e40609e, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 龙胆草

    学习谢谢分享

    0

  8. 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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sun Dec 31 07:45:58 CST 2017, time=2017-12-31, status=1, ipAttribution=)]
    2017-12-31 深海的鱼

    希望更少的副作用

    0

  10. 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    2017-12-31 Y—xianghai

    学习了新知识

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