Chest:肺梗死:肺动脉栓塞和出现肺梗死相关症状体征的时间间隔

2017-07-15 xiangting MedSci原创

肺动脉栓塞和出现肺梗死相关症状和体征的临床静默时间间隔为24小时或以上。

大面积肺栓塞可引起突发症状同时伴大肺动脉闭塞。相比之下,较小栓塞的肺血管与肺梗死症状发展之间的时间关系仍是未知的。这项研究描述了栓塞与出现和肺梗死相关临床症状和体征的时间间隔。

研究人员查阅了在单中心进行肺动静脉畸形(PAVMs)治疗性气囊栓塞的56例遗传性出血性毛细血管扩张症(HHT)患者的病历,其中一些出现了与肺梗死相关的症状和体征。由于栓塞时间和临床症状的出现时间都记录在病历中,因此研究人员可以计算血管栓塞和症状出现之间的时间间隔。

共检查了56例经过治疗性栓塞的HHT患者记录。其中5例在栓塞后出现单发性胸膜痛,1例在两次单独的栓塞手术后出现胸膜痛。其中4例胸膜痛事件演变成与肺梗死相关的复合体。出现梗死症状和体征的栓塞与胸膜痛出现的时间间隔为 24小时、48±4小时、65小时和67小时。

由此可见,肺动脉栓塞和出现肺梗死相关症状和体征的临床静默时间间隔为24小时或以上。

原始出处:
Peter B. Terry,et al. Pulmonary Infarction: In the Beginning. Chest. 14 July 2017.

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