JACC:肺癌患者心脏辐射剂量与不良预后相关

2019-06-23 不详 MedSci原创

局部非小细胞肺癌(NSCLC)患者的放射治疗相关心脏毒性的研究受到样本量小和心脏终点无效的限制。本研究的目的旨在确定心脏辐射剂量是否为主要不良心血管事件(MACE)和全因死亡的预测因子。本研究纳入分析了748名接受胸部放疗的局部NSCLC患者,经过平均20.4个月时间的随访,77名患者出现有≥1个MACE(2年的累积发生率为5.8%,95% [CI]: 4.3%-7.7%),533名患者死亡。心脏

局部非小细胞肺癌NSCLC)患者的放射治疗相关心脏毒性的研究受到样本量小和心脏终点无效的限制。本研究的目的旨在确定心脏辐射剂量是否为主要不良心血管事件(MACE)和全因死亡的预测因子。

本研究纳入分析了748名接受胸部放疗的局部NSCLC患者,经过平均20.4个月时间的随访,77名患者出现有≥1个MACE(2年的累积发生率为5.8%,95% [CI]: 4.3%-7.7%),533名患者死亡。心脏接受的平均辐射剂量与MACE和全因死亡的发生风险明显相关。在非冠心病患者中,心脏平均辐射剂量与全因死亡风险明显相关(HR: 1.34; 95% CI: 1.06-1.69; p = 0.014),但在冠心病患者中,这种相关性不存在。

研究结果显示,对于局部非小细胞肺癌患者,心脏接受的辐射剂量是主要不良心血管事件和全因死亡风险的预测因子。

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    2019-06-25 hbwxf
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    2019-06-25 jiyangfei
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    2019-06-24 百草

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