JAMA Network Open:ADHD 药物或可降低儿童的自杀风险!

2021-06-07 MedSci原创 MedSci原创

在全球范围内,儿童的自杀率一直在稳步上升。

在全球范围内,儿童的自杀率一直在稳步上升。根据疾病预防控制中心数据显示, 2018年,在10 24 岁人群中,自杀是第二大死因。注意缺陷/多动障碍 (ADHD) 是一种常见的神经发育障碍,通常在儿童时期被诊断出来,全球学龄儿童的患病率为 5% 7%ADHD 与多种精神疾病相关,包括自杀意念、自杀未遂和完成自杀,即使在控制了其他共存的精神健康障碍之后也是如此。

CCO

ADHD起病于童年期,影响可延续至成年,其主要特征是与发育水平不相称的注意缺陷和(或)多动冲动。ADHD不仅损害学习功能,还存在其他多方面、涉及生命全周期的损害。有研究显示, ADHD 药物治疗与自杀行为的关联。然而,这些数据依赖于临床表型或保险索赔等,需要更多有关于儿童使用 ADHD 药物与自杀潜在相关性的数据。近日,发表在JAMA Network Open杂志的一项研究显示,ADHD药物治疗可能会降低儿童自杀风险。

在这项队列研究中,研究人员使用来自美国青少年大脑认知发展 (ABCD) 研究的数据,ABCD 研究中收集的大量数据和广度使研究团队能够控制多个混杂因素,并具体剖析 ADHD 药物与自杀倾向之间的关联。本研究共纳入11878 名儿童,年龄在9-11岁,其中男孩占52.2%8.5% 的儿童接受了 ADHD 药物治疗,如哌甲酯、阿得拉或可乐定,8.8% 的儿童报告过去或现在有自杀倾向。

结果显示,与没有自杀倾向的儿童相比,表现出自杀倾向的儿童有更多的ADHD样症状,并且更有可能接受 ADHD 药物治疗。然而,在表现出明显的ADHD样症状的儿童中,服用 ADHD 药物自杀的可能性较小,这表明 ADHD 药物在这些儿童中具有调节作用。

为了研究这种影响是否持久,研究人员分析了1年后随访数据发现,在基线时接受 ADHD 药物治疗的ADHD样症状严重的儿童1年后自杀的可能性较小。基线时未接受 ADHD 药物治疗但ADHD样症状严重的儿童在1年后更有可能自杀。

研究人员表示,儿童使用 ADHD 药物可进行早期诊断和治疗,尤其是在有严重的ADHD样症状的儿童,不仅可以改善学习和行为问题,还能降低自杀风险。另外,鉴于儿童自杀倾向与成人心理健康状况不佳之间存在联系,因此,更好、更彻底地筛查学龄儿童的外在精神病理学,可以预防和减轻生命后期严重精神病风险。

总之,这项研究发揭示ADHD 药物与具有高ADHD样症状儿童的自杀率较低有关,男女都是如此。ADHD药物ADHD样症状儿童进行早期诊断和治疗,以减少潜在地儿童自杀率。

原始出处

Gal Shoval, MD1,2Elina Visoki, MSc3,4Tyler M. Moore, PhD4,5et al.Evaluation of Attention-Deficit/Hyperactivity Disorder Medications, Externalizing Symptoms, and Suicidality in Children.JAMA Network Open (2021). DOI: 10.1001/jamanetworkopen.2021.11342

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    2021-09-18 feather89
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    2021-06-19 canlab
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    2021-06-09 lg.zhao
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    2021-06-08 旺医

    顶刊就是顶刊,谢谢williamhill asia 带来这么高水平的研究报道,williamhill asia 科里同事经常看williamhill asia ,分享williamhill asia 上的信息

    0

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