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J Rheumatol：血清壳三糖酶水平在抗MDA5抗体阳性皮肌炎—相关间质性肺病中的意义

2019-05-29 xiangting MedSci原创

壳三糖酶抗MDA5DM/CADM-ILD
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血清壳三糖酶是预测抗MDA5阳性DM/CADM-ILD患者预后不良的潜在生物标志物。

这项研究旨在评估抗黑色素瘤分化相关基因5抗体（抗MDA5）阳性皮肌炎/临床无肌病性DM-相关间质性肺病（DM/CADM-ILD）的预后因素，并评估血清壳三糖酶（巨噬细胞活化标志物）作为抗MDA5阳性DM/CADM-ILD潜在生物标志物的作用。

本回顾性研究纳入了30名抗MDA5阳性的DM/CADM-ILD患者。分析诊断时的临床特征和实验室检查结果。测定了30名患者、21名健康对照和25名抗氨基酰-tRNA合成酶抗体阳性（抗ARS）-多发性肌炎（PM）/DM/CADM-ILD患者的血清壳三糖酶水平，并评估了血清壳三糖酶作为抗MDA5阳性DM/CADM-ILD预后生物标志物的潜能。

抗MDA5阳性DM/CADM-ILD患者血清壳三糖酶水平的中位数为17.3ng/ml，高于健康对照和抗ARS-PM/DM/CADM-ILD患者（分别为2.0和8.9 ng/ml）。30名患者中，10名死于与DM/CADM-ILD恶化相关的呼吸衰竭。Cox危险分析表明，血清壳三糖酶水平高和PaO2低是预后不良的重要指标。根据受试者工作特征曲线分析使用最佳阈值水平，壳三糖酶≥23.5ng/ml、铁蛋白≥800ng/ ml、Ⅱ型肺泡细胞表面抗原≥720U/ml与预后不良显著相关。血清壳三糖酶水平与PaO2和用力肺活量占预计值百分比呈负相关。壳三糖酶水平高（≥23.5ng/ml）的患者生存率明显低于壳三糖酶水平低的患者（<23.5ng/ml）。

血清壳三糖酶是预测抗MDA5阳性DM/CADM-ILD患者预后不良的潜在生物标志物。

原始出处：

Tomoyuki Fujisawa. Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody-positive Dermatomyositis-associated Interstitial Lung Disease. J Rheumatol. 15 May 2019.

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    2020-01-19 amy0559

    #肺病#

    0

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    2019-07-31 zjshifan_98647306

    #间质性#

    0

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    2019-09-28 41514487@qq.com

    #抗体阳性#

    0

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    2020-01-29 wetgdt

    #MDA#

    0

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    2019-10-25 lancelotzzl

    #抗MDA5抗体#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1671925, encodeId=718616e192580, content=<a href='/topic/show?id=58378220131' target=_blank style='color:#2F92EE;'>#肺病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82201, encryptionId=58378220131, topicName=肺病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f0826868454, createdName=amy0559, createdTime=Sun Jan 19 08:47:00 CST 2020, time=2020-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815798, encodeId=06b61815e98ad, content=<a href='/topic/show?id=82e99e291b0' target=_blank style='color:#2F92EE;'>#间质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97291, encryptionId=82e99e291b0, topicName=间质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Wed Jul 31 10:47:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1948111, encodeId=37521948111d3, content=<a href='/topic/show?id=3aae55212db' target=_blank style='color:#2F92EE;'>#抗体阳性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55212, encryptionId=3aae55212db, topicName=抗体阳性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/3239AC2A9C7E6019A0BC3C0489A21F7A/100, createdBy=c6a52500178, createdName=41514487@qq.com, createdTime=Sat Sep 28 06:47:00 CST 2019, time=2019-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1943554, encodeId=eb97194355424, content=<a href='/topic/show?id=daad11404a3' target=_blank style='color:#2F92EE;'>#MDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11404, encryptionId=daad11404a3, topicName=MDA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e34303, createdName=wetgdt, createdTime=Wed Jan 29 10:47:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1997675, encodeId=2bc4199e675c1, content=<a href='/topic/show?id=bfaf55110de' target=_blank style='color:#2F92EE;'>#抗MDA5抗体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55110, encryptionId=bfaf55110de, topicName=抗MDA5抗体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Oct 25 18:47:00 CST 2019, time=2019-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309276, encodeId=d1ef13092e697, content=<a href='/topic/show?id=e947e198270' target=_blank style='color:#2F92EE;'>#皮肌炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71982, encryptionId=e947e198270, topicName=皮肌炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=467c360, createdName=yuanming7, createdTime=Fri May 31 05:47:00 CST 2019, time=2019-05-31, status=1, ipAttribution=)]
    2019-05-31 yuanming7

    #皮肌炎#

    0