Heart:炎症性疾病会增加心血管代谢事件的风险吗?

2017-12-28 王淳 环球医学

2017年12月,发表在《Heart》上的一项研究,对不同炎症性疾病与心血管代谢事件风险的相关性进行了考察。

2017年12月,发表在《Heart》上的一项研究,对不同炎症性疾病与心血管代谢事件风险的相关性进行了考察。

目的:本研究旨在在一个基于社区的人群中,评估炎症性疾病与心血管代谢性疾病和死亡率之间的相关性。

方法:采用英国生物样本库开展了两项调查:横断面研究考察心血管代谢风险和前瞻性队列研究考察死亡风险。采用二元回归分析模型分析冠心病、卒中、2型糖尿病、静脉血栓栓塞和外周动脉疾病诊断与7种炎症性疾病(例如,类风湿关节炎(RA)、系统性红斑狼疮(SLE)、银屑病、强直性脊柱炎(AS)、系统性血管炎、克罗恩氏病和溃疡性结肠炎(UC))的关联。采用Cox比例风险模型估算全因和心血管相关死亡率。

结果:大约4%(n=19082)的研究人群(n=502641)被确诊为慢性炎症性疾病。最常见的炎症性疾病是银屑病(n=6286),最少见的是SLE(n=654)。SLE与心血管代谢疾病的多种[风险比(RR) 6.36,95%CI 4.37至9.25]风险相关性最强,其次是RA(RR 1.70,95% CI 1.59至1.83)、UC(RR 1.69,95% CI 1.51至1.89)、AS(RR 1.28,95% CI 1.09至1.52)、血管炎(RR 1.64,95% CI 1.42至1.90)和银屑病(RR 1.25,95% 1.16至1.35)。在处方非甾体抗炎药或糖皮质激素的患者中相关性的强度更高,在SLE中多种心血管代谢风险更高(RR 12.35,95%CI 7.18至21.24),其次是UC(RR 3.81,95% CI 2.69至5.38)、克罗恩氏病(RR 3.07,95% CI 1.85至5.11)、RA(RR 3.07,95% CI 1.85至5.11)、AS(RR 2.25,95% CI 1.48至3.41)和血管炎(RR 1.89,95% CI 1.28至2.79)。在累积的心血管代谢风险中也观察到相似的模式。

结论:炎症性疾病与升高的心血管代谢事件风险相关,且可能因抗炎治疗方法和持续时间而不同。同无炎症性疾病相比,特异性炎症性疾病的全因死亡也较高。

原始出处:

Dregan A,et al. Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders.Heart. 2017 Dec;103(23):1867-1873. doi: 10.1136/heartjnl-2017-311214. Epub 2017 Jun 10.

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    2018-01-02 大爰

    学习了谢谢分享!!

    0

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    2017-12-30 zhaojie88
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    2017-12-30 slcumt
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    2017-12-28 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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