Int J Stroke:原发性脑出血后,微出血的发生率较高

2015-09-18 MedSci MedSci原创

背景:研究人员在以非裔美国人为主的人群中调查了脑出血后,微出血发生次数,并且识别新发微出血的预测因子。 目的和假设:调查脑出血后新发微出血的频数以及预测因子。方法:这项研究是一项前瞻性,纵向,磁共振为基础的队列研究,主要评估微出血危险因素的种族差异,以及评估这类脑出血人群中微出血的预后。研究人员评估了两个时间段的新发微出血:基线到30天间和30天到1年间。结果:共招募200名受试者,84名患者MR

背景:研究人员在以非裔美国人为主的人群中调查了脑出血发生后,微出血发生的次数,并且识别新发微出血的预测因子。

目的和假设:调查脑出血后新发微出血的频率以及预测因子。

方法:这项研究是一项前瞻性,纵向,磁共振为基础的队列研究,主要评估微出血危险因素的种族差异,以及评估这类脑出血人群中微出血的预后。研究人员评估了两个时间段的新发微出血:基线到30天间和30天到1年间。

结果:共招募200名受试者,84名患者MRI显示满足的分析要求。在基线到30天这一时间段的分析中,11(13.1%)名患者存在新发微出血,30天到1年间,有25(29.8%)名受试者存在新发出血。Logistic回归分析显示,微出血的基线值(OR:1.05,95%CI:1.01,1.08)与30天新发微出血相关。Logistic回归模型显示能预测一年内新发微出血:包括微出血基线值(OR:1.05 95%CI:1.00, 1.11),基线年龄(OR:1.05 95%CI:1.00, 1.10),以及白质疾病分数(OR:1.18 95%CI:0.96, 1.45)。总之,84名患者中28名(33.3%)在脑出血后一年形成新发微出血。

结论:研究人员发现1/3的脑内出血的患者,一年内形成新发微出血,表明血管病变多样化快速进展。需要进一步研究新发微出血对患者预后的影响。

原文出处:

Mackey J, Wing JJ, Norato G,et al.High rate of microbleed formation following primary intracerebral hemorrhage. Int J Stroke. 2015 Aug 26.

 

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