Int J Biol Macromol:柠檬酸交联的NaCMC-HPMC水凝胶膜可用作伤口敷料

2019-05-13 不详 网络

该研究中,研究人员使用柠檬酸(CA)作为交联剂,由羧甲基纤维素钠(NaCMC)和羟丙基甲基纤维素(HPMC)制备水凝胶膜。通过FTIR分析证实NaCMC和HPMC之间的化学交联(酯键)。基于NaCMC-HPMC(2wt%)的水凝胶膜的溶胀度、结晶度和水接触角随着CA从5%增加至20%(按重量计)而降低。水凝胶膜的拉伸强度降低,而断裂伸长率(%)随着CA的增加而增加。通过FESEM和压汞孔隙率测定法

该研究中,研究人员使用柠檬酸(CA)作为交联剂,由羧甲基纤维素钠(NaCMC)和羟丙基甲基纤维素(HPMC)制备水凝胶膜。

通过FTIR分析证实NaCMC和HPMC之间的化学交联(酯键)。基于NaCMC-HPMC(2wt%)的水凝胶膜的溶胀度、结晶度和水接触角随着CA从5%增加至20%(按重量计)而降低。水凝胶膜的拉伸强度降低,而断裂伸长率(%)随着CA的增加而增加。通过FESEM和压汞孔隙率测定法发现高度互连的纳米多孔网络和低温固定水凝胶薄膜中平均孔径从微米到纳米尺寸的减小。与四环素相比,亚甲蓝的水凝胶膜的载药效率明显更高。水凝胶膜以持续的方式释放药物72小时。在37℃下在PBS(pH7.4)中释放三天后,水凝胶膜显示出明显的抗菌活性。

总之,这些发现表面本研究所制备的水凝胶膜可用作潜在的伤口愈合材料。

原始出处:

Dharmalingam K, Anandalakshmi R. Fabrication, characterization and drug loading efficiency of citric acid crosslinked NaCMC-HPMC hydrogel films for wound healing drug delivery applications. Int J Biol Macromol. 2019 May 8. pii: S0141-8130(19)31237-1. doi: 10.1016/j.ijbiomac.2019.05.027. 

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    2019-08-09 guozhenyu
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encodeId=14f0146101954, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542156, encodeId=bc2b154215647, content=<a href='/topic/show?id=669d6185e3e' target=_blank style='color:#2F92EE;'>#柠檬酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61857, encryptionId=669d6185e3e, topicName=柠檬酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=725913361726, createdName=ms5236388012055669, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2020-04-21 sunylz
  5. 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    2020-01-20 yb6560
  6. 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    2019-05-15 tastas
  7. 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    2019-05-15 10518094zz
  8. 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objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1400428, encodeId=832f1400428f4, content=<a href='/topic/show?id=e7c018e7af' target=_blank style='color:#2F92EE;'>#ACR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1877, encryptionId=e7c018e7af, topicName=ACR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=19792261142, createdName=10518094zz, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1461019, encodeId=14f0146101954, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1542156, encodeId=bc2b154215647, content=<a href='/topic/show?id=669d6185e3e' target=_blank style='color:#2F92EE;'>#柠檬酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61857, encryptionId=669d6185e3e, topicName=柠檬酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=725913361726, createdName=ms5236388012055669, createdTime=Wed May 15 04:32:00 CST 2019, time=2019-05-15, status=1, ipAttribution=)]
    2019-05-15 lishizhe
  9. 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