CSCO 2014:晚期胃癌腹膜转移的处理对策

2014-09-19 廖莉莉 中国医学论坛报

        复发转移性胃癌">胃癌综合治疗论坛(2楼3号会议室)时间:9月20日09:30~10:00         报告者:复旦大学附属中山医院刘天舒 胃癌中腹膜转移约占40%~50%,胃癌腹膜转移自然病程的平均生存时

        复发转移性胃癌">胃癌综合治疗论坛(2楼3号会议室)时间:9月20日09:30~10:00

        报告者:复旦大学附属中山医院刘天舒

胃癌中腹膜转移约占40%~50%,胃癌腹膜转移自然病程的平均生存时间和中位生存时间分别为6.5个月和3.1个月,预后极差,如不予以治疗严重威胁患者生命,但目前为止,并无行之有效的国际认可的标准治疗方案,因此胃癌腹膜转移的诊疗模式值得深入探讨。目前普遍被接受的仍然是Paget提出的“种子——土壤学说”,即单个肿瘤细胞从原发部位脱落,这些游离的肿瘤细胞分散于腹腔液中,肿瘤细胞分泌细胞因子等,引起腹膜发生纤维化等变化,为腹膜转移提供“土壤”,肿瘤细胞与腹膜间皮细胞通过细胞间黏附分子1和CD44等直接相互作用,打开腹膜间皮细胞之间的细胞连接,到达腹膜间皮的细胞外基质,通过整合素等引起基质降解,肿瘤细胞侵袭进入间皮下层,继续浸润性恶性生长。

胃癌细胞脱落至腹腔与胃癌是否侵及胃浆膜及侵犯胃浆膜的面积大小有关。会上,将围绕晚期胃癌腹膜转移的处理对策展开具体论述。

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    2017-06-11 luominglian113

    学习了,谢谢分享

    0

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    2014-09-21 xuyong530

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