Hypertension:父母身高与先兆子痫风险!

2018-02-21 xing.T MedSci原创

由此可见,产妇身高与先兆子痫的相关性不大可能是由于家族、社会经济因素或与身高有关的胎儿基因混杂所致。孕妇身高与先兆子痫之间的相关性值得进一步研究。

先兆子痫的病因尚不清楚。已有研究发现高个子女性妊娠时先兆子痫的发病率较低。这表明存在可能的生物因果效应,但可能是由于社会经济混杂所致。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员使用父母的身高作为未公开的对照来评估混杂因素。

研究人员从挪威母亲和儿童的队列研究(MoBa)中提取了99968例单胎妊娠中父母的身高、孕妇孕前体重、其他背景因素和妊娠结局等数据。根据父母身高,研究人员采用多因素logistic回归估计先兆子痫的比值比。

研究人员身高超过172cm的孕妇相比于身高低于164cm的孕妇发现调整后的先兆子痫比值比为0.74(95%可信区间为0.66-0.82)。与身高低于178cm的父亲相比于身高超过186cm的父亲,孕妇发生先兆子痫的调整比值比为1.03(95%可信区间为0.93-1.15)。

由此可见,产妇身高与先兆子痫的相关性不大可能是由于家族、社会经济因素或与身高有关的胎儿基因混杂所致。孕妇身高与先兆子痫之间的相关性值得进一步研究。

原始出处:

Yunsung Lee,et al. Maternal and Paternal Height and the Risk of Preeclampsia. Hypertension.2018. https://doi.org/10.1161/HYPERTENSIONAHA.117.10477

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    2018-08-20 feather89
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    2018-02-23 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-02-21 明崖

    学习了.期待进一步研究

    0

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    2018-02-21 wqkm

    ^_^^_^^_^

    0

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    2018-02-21 龙胆草

    学习谢谢分享

    0

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