Prostate:双酚A与饮酒对良性前列腺增生的影响

2021-09-21 AlexYang MedSci原创

评估了长期双酚A暴露与良性前列腺增生风险之间的关系,并探讨了这种关联是否受饮酒影响。

目前,双酚A(BPA)能否导致良性前列腺增生(BPH)仍旧不清楚。

近期,来自香港中文大学的研究人员在《Prostate》上发表文章,评估了长期双酚A暴露与良性前列腺增生风险之间的关系,并探讨了这种关系是否受饮酒影响

研究包括了2011-2016年期间,从香港同一家医院招募的总共650名BPH病例和650名对照。通过累积BPA暴露指数(CBPAI)评估了长期BPA暴露水平。非条件逻辑回归模型调查了良性前列腺增生风险与潜在BPA暴露源的关系。之后,又进一步检查了CBPAI与饮酒对BPH风险的交互作用。

结果发现,CBPAI与BPH风险之间存在正向暴露-反应关系。经常摄入塑料盒/袋中加热的食物(几率[OR]=3.52,95%置信区间[CI]:1.51-8.22)、用塑料瓶冷却水(OR=2.65,95%CI:1.33-5.27)或使用塑料杯装热水(OR=4.14,95%CI:1.02-16.89)将会导致经常暴露于BPA,并与BPH风险增加显著相关。与不饮酒者相比,饮酒者与良性前列腺增生风险无明显关联(OR=1.10,95% CI: 0.77-1.57),但在饮酒者中,CBPAI暴露与良性前列腺增生风险之间表现出更明显的正向关系,表明CBPAI和酒精对良性前列腺增生风险存在加性作用(协同指数=4.24,95% CI: 1.21-14.94)。

饮酒与累积双酚A暴露水平对良性前列腺增生风险的作用情况

综上所述,长期暴露双酚A会增加良性前列腺增生的风险,并且饮酒会增强双酚A对前列腺增生的影响。因此,研究人员建议社区尽量减少用塑料容器盛装食物或水/饮料以及减少饮酒,从而达到降低前列腺增生风险的目的。

原始出处:

Gengze Liao , Priscilla M Y Lee , Shi Zhao et al. Joint effect between bisphenol A and alcohol consumption on benign prostatic hyperplasia: A case-control study in Hong Kong Chinese males. Prostate. Aug 2021

 

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    2021-09-23 zhaojie88
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    2021-09-23 lsndxfj
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    2021-09-23 sunylz
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    2021-09-22 查查佳佳

    啊路我发五里桥梁噢啦?慕课

    0

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    2021-09-21 smart Ren

    学习学习

    0

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