J Periodontol:健康人与慢性牙周炎、心肌梗死患者内皮功能的比较

2017-11-23 MedSci MedSci原创

重度牙周病患者内皮细胞会有损害,内皮功能的破坏有助于动脉粥样硬化斑块的形成,进而可能成为冠状动脉疾病的风险。本研究的目的是通过血管舒张功能(FMD)评估牙周健康和疾病中的内皮功能。

重度牙周病患者内皮细胞会有损害,内皮功能的破坏有助于动脉粥样硬化斑块的形成,进而可能成为冠状动脉疾病的风险。本研究的目的是通过血管舒张功能(FMD)评估牙周健康和疾病中的内皮功能。

实验选取120例患者,随机分为3组:1)健康(对照); 2)慢性牙周炎(CP);和3)心肌梗塞(MI)。评估所有患者的牙周发炎表面积(PISA)和FMD。空腹抽取血样以检测血脂。用方差分析比较脂质,Kruskal-Wallis检验比较各组中FMD和PISA评分,P <0.05。

结果:三组间FMD水平比较的差异有统计学意义,P <0.001。当健康组与CP和MI组比较时,该值具有统计学意义,而CP组与MI组之间不具有统计学意义。在健康组和CP组之间以及CP组和MI组之间的血脂质分布水平在统计学上意义显着。

结论:与健康患者相比,CP患者的内皮功能受损,与MI组的FMD值相似。

原始出处:

Anahita Punj, et al. Comparison of Endothelial Function in Healthy Patients and Patients With Chronic Periodontitis and Myocardial Infarction. Journal of Periodontology . 2017 December. doi: 10.1902/jop.2017.160748

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