STM:小型临床研究为白血病病人展现免疫治疗新希望

2016-09-23 佚名 生物谷

对于出现治疗后复发或从开始就不对治疗产生应答的急性髓系白血病病人来说,一种新型的免疫治疗方法展现出对抗急性髓系白血病的新希望。华盛顿大学医学院进行的一项小型临床试验提供证据表明免疫系统中的自然杀伤细胞(NK)可以在实验环境下被调动起来,重新激活并有效清除部分病人体内的癌细胞。相关研究结果发表在国际学术期刊Science Translational Medicine上。在最终得到评估的9名病人中有5


对于出现治疗后复发或从开始就不对治疗产生应答的急性髓系白血病病人来说,一种新型的免疫治疗方法展现出对抗急性髓系白血病的新希望。华盛顿大学医学院进行的一项小型临床试验提供证据表明免疫系统中的自然杀伤细胞(NK)可以在实验环境下被调动起来,重新激活并有效清除部分病人体内的癌细胞。相关研究结果发表在国际学术期刊Science Translational Medicine上。

在最终得到评估的9名病人中有5人可以观察到能够对治疗产生应答。4名病人实现病情的完全缓解,在治疗后至少一个月内出现白血病复发的迹象。1名病人得到部分缓解,治疗后一个月重新出现了异常细胞。剩下的4名病人没有对治疗产生应答。最长的完全缓解时间持续了大约6个月,而相比之下,对治疗不产生应答的AML病人平均生命期限只有3个月。

“这虽然只是一项小型研究,但是50%的应答率已经说明这种免疫治疗方法非常有希望,并且参与研究的病人预后很差,他们的治疗选择很少,”文章作者Todd A. Fehniger教授这样说道。“其中有一些岁数比较大的病人已经不适合进行传统的骨髓移植。”

这项研究采用的治疗方法是将高度纯化的自然杀伤细胞(NK)导入病人体内。在这项临床试验中还有另外4名病人接受了NK细胞治疗,其中3人在试验结束前死于血流感染,1人由于供体提供的NK细胞数量不足,没有接受完整剂量的治疗。

一般来说,AML病人会因为化疗对免疫系统的抑制导致发生感染的风险增加。据研究人员介绍参与这项试验的病人的病情更加严重,他们已经用尽了所有的治疗选择,只能选择参加临床试验或进入临终安养院。

“williamhill asia 对这些结果持谨慎乐观的态度,”Fehniger表示。“一个病人对治疗产生何种应答存在许多可能,但是这种免疫治疗方法似乎能够帮助病人缓解病情,而其他的治疗方法包括类似的免疫治疗都已经不能发挥作用。”

原始出处

Rizwan Romee1,*, Maximillian Rosario1,2,*, Melissa M. Berrien-Elliott1,*, Julia A. Wagner1, Brea A. Jewell1,Timothy Schappe1, Jeffrey W. Leong1, Sara Abdel-Latif1, Stephanie E. Schneider1, Sarah Willey1, Carly C. Neal1, Liyang Yu3, Stephen T. Oh3, Yi-Shan Lee2, Arend Mulder4, Frans Claas4, Megan A. Cooper5 and Todd A. Fehniger.Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia.STM.2016


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    2017-06-25 gdsun
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    2016-10-13 珙桐
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    2016-10-11 童小孩

    免疫治疗是新的希望

    0

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    2016-09-26 axzpiglet

    有前途,不过疗效还有待进一步肯定

    0

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    2016-09-24 1e0d99ddm02(暂无匿称)

    总结的很好!!!

    0

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    2016-09-24 刘煜

    学习了谢谢。

    0

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