脖子越粗,心脏代谢风险越高!

2021-02-18 MedSci原创 MedSci原创

众所周知,内脏脂肪的积累被认为是与人类心脏代谢风险和低级别慢性炎症最为密切相关的因素之一。然而,这种既定的关联导致研究人员在一定程度上忽视了其他脂肪沉积及其临床/生物学相关性的研究。

众所周知,内脏脂肪的积累被认为是与人类心脏代谢风险和低级别慢性炎症最为密切相关的因素之一。然而,这种既定的关联导致研究人员在一定程度上忽视了其他脂肪沉积及其临床/生物学相关性的研究。

事实上,颈部脂肪堆积对健康影响的证据都是基于对良性/恶性肿瘤或其他慢性疾病患者进行的试验,那么,是否能推广到相对健康的成年人。近日,发表在International Journal of Obesity杂志的一项研究显示,在颈部组织区域脂肪沉积,尤其是颈椎周围更深处,与更大的心脏代谢风险密切相关。

在这项横断面研究中,研究人员收纳了139名健康年轻的成年人,其中女性占68%,通过计算机断层扫描,以量化在椎体C5高度的房室(即皮下、肌间和椎体周围)NAT体积总和,并使用双能X射线吸收测定法确定脂肪的组成。另外,还收集了与心脏代谢风险的相关因素,如血糖和脂质标志物,血压和身体健康状况,并对血浆细胞因子和血清水平进行测定,以确定炎症状态。

研究结果显示,脂肪在颈部的堆积,既有双下巴或下颚等浅表的沉积,也有位于肌肉之间和颈部周围较深的沉积,这与体重或肥胖程度直接相关。而且,颈部脂肪堆积,尤其是肌间,与发生更大的心脏代谢风险以及炎症有关。然而,与高密度脂蛋白-胆固醇(HDL-C)以及脂肪蛋白浓度呈反向相关。

与BMI类别相关的颈部测量平均值(和标准差)

研究人员进一步观察到,在预测心脏代谢风险和炎症状态方面,尤其是在男性中,颈部脂肪的积累与内脏脂肪的积累一样是一个强大的因素。

综上,颈部脂肪的堆积及其在不同组织间的分布与年轻健康成人心脏代谢风险和炎症发生相关。这项结果强调,研究人员需要更深入地研究颈部的脂肪组织,以更好地了解脂肪堆积在躯干上部(包括颈部)的临床影响以及其生物学意义。

原始出处

Maria Jose Arias-Tellez et al. Neck adipose tissue accumulation is associated with higher overall and central adiposity, a higher cardiometabolic risk, and a pro-inflammatory profile in young adults, International Journal of Obesity 2020. DOI: 10.1038/s41366-020-00701-5

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    2021-02-19 ms3000001962617292

    关注点甚为刁钻

    0

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    2021-02-18 Campo

    入木三分

    0

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    2021-02-18 jyzxjiangqin

    好文章!

    0

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    2021-02-18 jyzxjiangqin

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