药物诱发痛风急性发作1例

2018-02-11 佚名 右江民族医学院学报

患者,男,63岁

【一般资料】

患者,男,63岁

【主诉】

因“解黑便7d”非急诊入院

【现病史】

患者自诉7d前无明显诱因下出现解黑便,量少,伴乏力,恶心,头晕,眼花,四肢关节疼痛,无呕吐,呕血,腹痛,腹胀,腹泻,无畏寒,发热,咳嗽,咳痰,胸痛,头痛,心悸,晕厥等其它不适症状,病后曾到当地县医院就诊,诊断:①上消化道出血;②失血性贫血;③痛风。经抑酸护胃止血,输血等对症治疗后,已无解黑便,但四肢关节肿痛无明显缓解,今为求进一步诊治而来我院,门诊拟诊断:①上消化道出血;②痛风,收入我科住院治疗。自起病以来,精神尚可,睡眠,食欲差,小便正常,大便如上述,体重未见明显改变。

【既往史】

既往有痛风病史10余年,长期口服激素,止痛药治疗;40余年饮酒史,饮白酒(20°)约1斤/天,已戒2周;曾有“上消化道出血”2次;余史无特殊。

【体格检查】

T37.1℃,P96次/分,R20次/分,BP20.08/10.51kPa,神清,被动平卧位,贫血貌,全身皮肤黏膜轻度苍白,巩膜无黄染,浅表淋巴结未触及肿大,心?肺?腹检查未见阳性体征,双膝关节红肿,皮温高,压痛,四肢关节可见数颗大小不一的痛风石,神经系统检查结果为阴性。

【辅助检查】

血常规:白细胞12.4×109/L;中性粒细胞数11.22×109/L;中性粒细胞百分比90.50%;红细胞2.60×1012/L;血红蛋白65g/L;血沉56mm/h;尿酸455μmol/L,胃镜检查及分期:胃窦多发性溃疡(A2,H2) 

【初步诊断】

①上消化道出血(胃窦多发性溃疡);②痛风;③中度贫血 

【治疗】

入院后给予低嘌呤饮食,经过PPI类(兰索拉唑)药抑酸护胃,输血,口服碳酸氢钠,补液,改善循环及对症支持治疗后,上消化道出血基本控制,但四肢关节肿痛仍有反复,偶有痛风急性发作,随改用H2受体拮抗剂(西咪替丁)代替PPI类药(兰索拉唑),小剂量激素控制发作,关节肿痛较前缓解,痛风未再急性发作,病情好转出院。

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    2018-02-25 spake

    这个病人用非布司他合适么?

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=290739, encodeId=3d9b290e3953, content=这个病人用非布司他合适么?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/25/f9c103b74b05f7c5951ad79adf5be80f.jpg, createdBy=49642274853, createdName=spake, createdTime=Sun Feb 25 08:04:12 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554300, encodeId=c688155430004, content=<a href='/topic/show?id=8402522319e' target=_blank style='color:#2F92EE;'>#急性发作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52231, encryptionId=8402522319e, topicName=急性发作)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287314518946, createdName=anminleiryan, createdTime=Tue Feb 13 10:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287171, encodeId=086628e171f9, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Feb 11 22:11:37 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287153, encodeId=301328e15326, content=好病例.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 11 19:53:30 CST 2018, time=2018-02-11, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=290739, encodeId=3d9b290e3953, content=这个病人用非布司他合适么?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/25/f9c103b74b05f7c5951ad79adf5be80f.jpg, createdBy=49642274853, createdName=spake, createdTime=Sun Feb 25 08:04:12 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554300, encodeId=c688155430004, content=<a href='/topic/show?id=8402522319e' target=_blank style='color:#2F92EE;'>#急性发作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52231, encryptionId=8402522319e, topicName=急性发作)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287314518946, createdName=anminleiryan, createdTime=Tue Feb 13 10:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287171, encodeId=086628e171f9, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Feb 11 22:11:37 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287153, encodeId=301328e15326, content=好病例.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 11 19:53:30 CST 2018, time=2018-02-11, status=1, ipAttribution=)]
    2018-02-11 清风拂面

    谢谢分享学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=290739, encodeId=3d9b290e3953, content=这个病人用非布司他合适么?, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/02/25/f9c103b74b05f7c5951ad79adf5be80f.jpg, createdBy=49642274853, createdName=spake, createdTime=Sun Feb 25 08:04:12 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1554300, encodeId=c688155430004, content=<a href='/topic/show?id=8402522319e' target=_blank style='color:#2F92EE;'>#急性发作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52231, encryptionId=8402522319e, topicName=急性发作)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287314518946, createdName=anminleiryan, createdTime=Tue Feb 13 10:21:00 CST 2018, time=2018-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287171, encodeId=086628e171f9, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sun Feb 11 22:11:37 CST 2018, time=2018-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=287153, encodeId=301328e15326, content=好病例.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Feb 11 19:53:30 CST 2018, time=2018-02-11, status=1, ipAttribution=)]
    2018-02-11 1e0f8808m18(暂无匿称)

    好病例.学习了.

    0

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女,36岁,体重60kg,