Mucosal Immunol:激素类避孕药会增加HIV生殖道感染

2016-04-28 生物谷 生物谷

全世界感染艾滋病毒的患者约有一半是女性,研究人员想鉴别出增加女性生殖器感染易感性的风险因素。 俄亥俄州立大学医学中心的研究者发现,因为艾滋病毒和其它性传播病毒必须穿透生殖器粘膜屏障才能感染,所以研究人员试图找出削弱生殖器粘膜屏障防御的因素。 他们的研究最近发表在Mucosal Immunology杂志上,文章显示用甲孕酮(DMPA)或左炔诺孕酮(LNG)治疗后显著增加了雌性小鼠生殖道病毒感

全世界感染艾滋病毒的患者约有一半是女性,研究人员想鉴别出增加女性生殖器感染易感性的风险因素。

俄亥俄州立大学医学中心的研究者发现,因为艾滋病毒和其它性传播病毒必须穿透生殖器粘膜屏障才能感染,所以研究人员试图找出削弱生殖器粘膜屏障防御的因素。

他们的研究最近发表在Mucosal Immunology杂志上,文章显示用甲孕酮(DMPA)或左炔诺孕酮(LNG)治疗后显著增加了雌性小鼠生殖道病毒感染易感性。

具体来说,用DMPA或LNG治疗小鼠会导致上皮通透性增加从而减少生殖道屏障保护。较大的通透性增加了病毒的病原体侵入的机会。

“williamhill asia 的发现对DMPA和临床研究建议的生殖器易感性之间的关系提供了新的生物学合理性。” Thomas L. Cherpes博士说。“他们还确定, LNG可能同样增强了病毒感染的易感性。”

“值得注意的是,williamhill asia 对女性宫颈活检组织进行了评估,一个月后DMPA初步作用导致屏障保护减少了,这同黄体酮治疗的小鼠发生的改变相同。”Nirk Quispe Calla博士说。

另一方面,其他的小鼠研究者所进行的研究显示,用DMPA和阴道内的雌激素联合治疗通过恢复生殖器粘膜屏障来预防小鼠患2型单纯疱疹病毒,这是防御所有的性传播感染第一道防线。

“在一种可能的情况下,女性会接受DMPA和雌二醇释放阴道环,它会释放抗病毒杀菌剂。在这个时候只有一个假设的选择,williamhill asia 定义这种方法的安全性和有效性需要进一步研究。”Rodolfo Vicetti Miguel博士说。

原始出处:

N E Quispe Calla, R D Vicetti Miguel, P N Boyaka, L Hall-Stoodley, B Kaur, W Trout, S D Pavelko and T L Cherpes.Medroxyprogesterone acetate and levonorgestrel increase genital mucosal permeability and enhance susceptibility to genital herpes simplex virus type 2 infection.Mucosal Immunology , (23 March 2016) | doi:10.1038/mi.2016.22 doi: 10.1038/mi.2016.22

版权声明:
本网站所有内容来源注明为“williamhill asia 医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于williamhill asia 医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“williamhill asia 医学”。其它来源的文章系转载文章,或“williamhill asia 号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与williamhill asia 联系,williamhill asia 将立即进行删除处理。
在此留言
评论区 (6)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
    2016-04-30 bioon3
  4. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
    2016-04-29 南塘隐9d53fba6

    保护自己关注健康

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2054830, encodeId=02982054830ac, content=<a href='/topic/show?id=2884123537e' target=_blank style='color:#2F92EE;'>#Mucosa#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12353, encryptionId=2884123537e, topicName=Mucosa)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a5c2500147, createdName=12498bb3m90(暂无昵称), createdTime=Tue Jun 14 17:15:00 CST 2016, time=2016-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1706409, encodeId=25761e06409a6, content=<a href='/topic/show?id=267e6911875' target=_blank style='color:#2F92EE;'>#生殖道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69118, encryptionId=267e6911875, topicName=生殖道)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0e9f31248425, createdName=124984e7m93暂无昵称, createdTime=Sat Sep 17 22:15:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349748, encodeId=a36d1349e4812, content=<a href='/topic/show?id=3d0d134904c' target=_blank style='color:#2F92EE;'>#OSA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13490, encryptionId=3d0d134904c, topicName=OSA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466222, encodeId=30611466222c5, content=<a href='/topic/show?id=3311123548c' target=_blank style='color:#2F92EE;'>#mucosal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12354, encryptionId=3311123548c, topicName=mucosal)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Apr 30 05:15:00 CST 2016, time=2016-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83266, encodeId=0f638326609, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=83267, encodeId=478a8326eda, content=保护自己关注健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Fri Apr 29 09:13:00 CST 2016, time=2016-04-29, status=1, ipAttribution=)]
    2016-04-29 南塘隐9d53fba6

    保护自己关注健康

    0

相关威廉亚洲官网

NEJM:激素替代治疗可延缓早期绝经女性发生颈动脉粥样硬化

本研究旨在评估雌二醇(有或无孕激素)对颈动脉粥样硬化的影响。研究人员总共纳入643名健康的绝经女性,并根据更年期(< 6年[早期绝经后期]或≥10年[晚绝经后期])时间随机分配到两组中,一组给予17β-雌二醇1mg/日,另一组给予安慰剂。雌二醇组女性同时使用孕酮阴道凝胶,每日使用,连续10天,持续30天;安慰剂组女性以同样的用药方式使用安慰剂阴道凝胶。研究主要终点为6个月后测量女性的颈动脉内

J Allergy Clin Immunol:噻托溴铵+ICS可显著改善肺功能

近期发表在J Allergy Clin Immunol的研究称,患者在吸入糖皮质激素治疗背景下,服用噻托溴铵可显著改善肺功能,尤其是接受更大剂量的患者,肺功能改善更明显。德国比勒费尔德的Eckard Hamelmann博士写道:“青少年中度哮喘患者,在吸入糖皮质激素的基础上,每日服用一次噻托溴铵[Spiriva, Boehringer Ingelheim]可显著改善肺功能,改善哮喘的控制和生活质量

J Clin Invest:性激素与骨骼健康

背景:成年男性严重缺乏性激素会导致骨质流失;然而,缺乏雄激素和雌激素对性腺功能减退的骨丢失的具体作用仍不清楚。此外,启动骨损伤的睾酮和雌二醇的阈值水平是不确定的。方法:纳入198名20-50岁健康男性,服用醋酸戈舍瑞林(抑制内源性性激素产生),随机服用每天0、1.25、2.5、5或10g睾酮凝胶,共16周。一个纳入202名男性的额外队列在这些随机治疗的基础上,服用阿那曲唑(抑制雄激素向雌激素的转化

应激反应或促使癌症通过淋巴系统扩散

一项基于小鼠的研究发现,应激激素通过影响淋巴系统—— 一种在全身传输组织液的网状管道,可导致癌症扩散。研究表明针对这种应激通路的疗法或有助于阻断癌细胞扩散。相关成果近日发表于《自然—通讯》。 有证据表明应激反应和癌症患者死亡的增加以及动物晚期癌症的发展有关。此前的研究表明应激激素会影响血管形成,这在疾病扩散中很重要。淋巴系统也能促进癌症扩散,但这是否受到应激反应的影响却不清楚。 澳大利亚维多利

首次发现父亲心理应激影响子代糖代谢

上海交大医学院研究员陈学进课题组和瑞金医院教授李小英课题组合作,首次发现父亲的心理应激通过表观遗传等机制可调控子代的糖代谢状况,进一步证实了环境因素介导的跨代遗传调控作用。相关研究成果近日发表于《细胞代谢》。 大量人群流行病学研究表明,心理应激与多个疾病的发生发展密切相关。近来的研究表明,母亲的心理应激,尤其是妊娠期间的应激,可促进子代肥胖和Ⅱ型糖尿病的发生。但父亲应激能否影响或调控子代的糖

Cell:一种新的糖尿病相关激素被发现,有望成为新靶点

研究人员一开始只是想为罹患新生儿型类早衰症(NPS)的患儿寻求答案,这种罕见遗传病会阻止机体累积脂肪,结果现在却获得了一个有可能影响数百万2型糖尿病患者生活的研究发现。他们将研究结果发布在今天的《细胞》(Cell)杂志上。 论文的资深作者、贝勒医学院医学遗传学家Atul Chopra博士,首先在2013年发现了两名罹患这种罕见疾病的患者(全世界只有少数患者被描述患有此病,且病因未知)。在