GUT: COVID-19病毒对肝硬化患者生存率的影响

2020-07-18 MedSci原创 MedSci原创

COVID-19患者如果患有各种其他合并症那么其预后是不良的。数据显示,肝硬化患者可能是不良预后的高风险患者。但是,尚缺乏肝硬化+ COVID-19患者与仅COVID-19和仅肝硬化患者之间的结局比较

背景及目的:

COVID-19患者如果患有各种其他合并症那么其预后是不良的。数据显示,肝硬化患者可能是不良预后的高风险患者。但是,尚缺乏肝硬化+ COVID-19患者与仅COVID-19和仅肝硬化患者之间的结局比较。这项研究的目的是进行这些比较。

方法

研究人员进行了一项针对肝硬化+ COVID-19住院患者与年龄/性别匹配的仅COVID-19或单纯肝硬化患者的多中心研究。比较了COVID-19和肝硬化的特征,器官衰竭的发展以及慢性肝功能衰竭(ACLF)和死亡率。

结果

来自七家医院的37例肝硬化+ COVID-19患者与108例COVID-19患者和127例肝硬化患者被纳入研究。种族/民族相似。肝硬化+ COVID-19患者的死亡率高于COVID-19患者(30%vs 13%,p = 0.03),但在肝硬化+ COVID-19患者和肝硬化患者之间死亡率却不高(30%vs 20%,p = 0.16)。肝硬化+ COVID-19的患者与仅COVID-19的患者具有相同的呼吸道症状,胸部表现以及重症监护病房转移和通气率。但是,肝硬化+ COVID-19患者的查尔森合并症指数更差(CCI 6.5±3.1VS 3.3±2.5,p <0.001),GI症状降低,乳酸含量更高。单纯肝硬化患者的肝硬化相关并发症较高,与肝硬化+ COVID-19的患者相比,终末期肝病(MELD)评分的最高模型和更低的BiPAP需求。

结论

本项研究表明年龄/性别匹配的肝硬化+ COVID-19患者与单独的肝硬化患者相比具有相似的死亡率,但高于单独的COVID-19患者。

原始出处:

Jasmohan S Bajaj. Et al. Comparison of mortality risk in patients with cirrhosis and COVID-19 compared with patients with cirrhosis alone and COVID-19 alone: multicentre matched cohort. GUT. 2020.

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    2020-07-19 wangzheng00

    学习

    0

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    2020-07-18 guging

    谢谢!最新的信息读起来就是收获大

    0

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