BMJ Open：新生儿使用阿奇霉素的安全性研究

2016-01-06 Seven L 译 MedSci原创

研究者检索了MEDLINE、EMBASE、Pubmed等数据库中关于新生儿使用阿奇霉素的研究，以探究新生儿使用阿奇霉素和不良药物反应。该系统回顾纳入了使用过阿奇霉素的＜28天的新生儿，以与阿奇霉素相关的不良事件作为主要结局，而阿奇霉素在新生儿中的使用作为继发结局。最终该系统回顾纳入了11篇相关研究，涉及473名新生儿，数据报道了371例不良事件。不良反应时事件主要包括呼吸系统 (358/1000)

研究者检索了MEDLINE、EMBASE、Pubmed等数据库中关于新生儿使用阿奇霉素的研究，以探究新生儿使用阿奇霉素情况和不良药物反应情况。该系统回顾纳入了使用过阿奇霉素的＜28天的新生儿，以与阿奇霉素相关的不良事件做为主要结局，而阿奇霉素在新生儿中的使用作为继发结局。

最终该系统回顾纳入了11篇相关研究，涉及473名新生儿，数据报道了371例不良事件。不良反应时事件主要包括呼吸系统 (358/1000)、神经系统(273/1000)、胃肠道(196/1000) 起源的不良反应。研究者发现阿奇霉素可显著降低极早产新生儿支气管肺发育不良的风险 (RR=0.83, 95% CI 0.71 to 0.98, p=0.02)。阿奇霉素和对照组对肝酶的影响差异不大 (p=0.76)。纳入研究中有4例肥厚性幽门梗阻。

系统回顾数据表明，阿奇霉素可显著降低极早产新生儿支气管肺发育不良的风险，而阿奇霉素和肥厚性幽门梗阻间联系还需要更多的研究。

原始出处：

Smith C, Egunsola O,et al.Use and safety of azithromycin in neonates: a systematic review.BMJ Open. 2015 Dec 9;5(12):e008194.

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2016-11-20 gaoxiaoe

#BMJ#

51 0
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2016-07-06 feather89

#PE#

50 0
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2016-01-24 1de3b290m83(暂无匿称)

williamhill asia 用红霉素

115 0
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2016-01-12 ssummer

太简短啦，赶脚没写啥内容

182 0
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2016-01-11 三三五五

好的

87 0
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2016-01-06 dhzzm

值得学习

119 0
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2016-01-06 wzf990214

有意思

149 0
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2016-01-06 wzf990214

赞

88 0
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2016-01-06 wzf990214

牛

98 0

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