AJG:合并有精神症状的慢性胰腺炎患者其疼痛及生活质量均会明显恶化

2020-12-27 MedSci原创 MedSci原创

慢性胰腺炎(CP)是一种使人痛不欲生的胰腺疾病,它主要的症状是腹痛,超过80%的CP患者受到腹痛的影响。CP引起的腹部疼痛通常会使人衰弱,并降低生活质量(QOL)。

      慢性胰腺炎(CP)是一种使人痛不欲生的胰腺疾病,它主要的症状是腹痛,超过80%的CP患者受到腹痛的影响。CP引起的腹部疼痛通常会使人衰弱,并降低生活质量(QOL),先前的研究已经评估了QOL及其在CP中的决定因素,但使患者焦虑不安的抑郁症很大程度上未得到探究。有证据表明,疼痛和抑郁症具有双向影响:增加一个人的抑郁严重程度将导致对疼痛更为敏感。因此,本项研究旨在研究CP患者的焦虑和抑郁的患病率及其相关的患者和疾病特征以及对QOL的影响。

 

      这是一项横断面的多中心的前瞻性研究,研究人员使用焦虑和抑郁量表对患者进行筛查。在各自的焦虑或抑郁量表上,医院焦虑和抑郁量表得分> 7表示存在焦虑或抑郁,并被用作精神疾病合并症的诊断指标。最后研究人员比较了有和没有精神病合并症的患者的人口统计学,疾病特征,生活质量(EORTC-QLQ-C30)和疼痛症状的差异。

 

      本项研究共纳入111名CP患者(平均年龄53.8±13.7岁,男性占60%)。80(46.8%)和66(38.6%)名患者分别存在焦虑和抑郁,其中50人(29%)的焦虑和抑郁是重叠的。焦虑或抑郁症患者的疼痛发生率,疼痛严重程度和疼痛干扰评分较高(P <0.001)。精神病合并症也与全球健康评分和功能分量表降低有关(P <0.001),这些患者的临床症状负荷也更重(P ≤0.03)。最后,研究人员发现患者健康状况与抑郁之间存在独立的关联(P <0.001)。

 

      精神疾病在CP患者中普遍存在,并会加重疼痛和降低QOL评分。焦虑对QOL的影响可能通过疼痛来介导,而抑郁与QOL独立相关。

 

原始出处:

Phillips, Anna Evans. Et al. Psychiatric Comorbidity in Patients With Chronic Pancreatitis Associates With Pain and Reduced Quality of Life. The American Journal of Gastroenterology.2020.

 

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    2021-02-28 minzju5052
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    2020-12-27 oo902

    合并有精神症状的慢性胰腺炎患者其疼痛及生活质量均会明显恶化

    0

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    2020-12-27 oo902

    疼痛及生活质量均会明显恶化

    0

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    2020-12-27 GLL

    学习了

    0

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    2020-12-27 jyzxjiangqin

    好好学习!

    0

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    2020-12-27 ms6000001700483633

    已学习

    0

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