Radiology:CT引导下微弹簧圈定位联合胸腔镜手术切除哪种肺结节比较好?

2019-08-07 shaosai MedSci原创

背景与目的:CT引导下微弹簧圈定位能都减少胸廓切开术或胸腔镜下手术(VATS)解剖性切除。先前研究仅对经CT引导先微弹簧圈定位后肺切除进行了短期随访。本研究旨在评价CT引导下微弹簧圈定位联合VATS后诊断价值与无复发生存期大于2年的价值。

背景与目的:CT引导下微弹簧圈定位能都减少胸廓切开术或胸腔镜下手术(VATS)解剖性切除。先前研究仅对经CT引导先微弹簧圈定位后肺切除进行了短期随访。本研究旨在评价CT引导下微弹簧圈定位联合VATS后诊断价值与无复发生存期大于2年的价值。

本研究共收集了1950次VATS手术的资料,共有124例患者行CT引导微弹簧圈定位术。记录患者人口学特征、肺结节特征和组织病理学结果。最终结果为CT随访2年以上无复发生存。统计学方法包括Kaplan-Meier生存曲线和Cox回归分析。

结果为,在124例CT发现肺结节的患者中,共有126处肺结节进行了微弹簧圈定位联合VATS切除术。在术前CT评价中,实性结节、磨玻璃密度结节和亚实性结节分别为42% (53 / 126)、 33% (41 / 126) 、24% (30 / 126)。VATS切除性活检结果有21% (5 / 24)与诊断性CT引导下活检结果不一致。在组织病理学检查中,17% (21 / 126)为原位腺癌, 17% (22 / 126)为微浸润性腺癌,30% (38 / 126)为浸润性肺原发肿瘤,22% (28 / 126)为转移瘤。在72例组织学检查结果为恶性肿瘤且行至少2年CT随访的患者中,在CT随访2年以上后,局部复发、肺内复发和肺外复发分别为7% (five / 72)、22% (16 / 72)、18% (13 / 72)。原位癌、微浸润癌和<1cm的浸润癌均无复发。在多变量校正后,结节位置距胸膜超过10mm是预测复发时间的独立指标(HR为 2.9 [95%CI: 1.1, 7.4]; P = .03)。

本研究表明,CT引导下微弹簧圈定位联合胸腔镜手术能够改善临床管理,对癌前病变、微浸润和浸润性小肿瘤能获得较高的无复发生存期。

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