中国科学院大学&美国哈佛医学院:花生作为替代零食可降低我国成年人代谢综合征风险

2021-01-06 MedSci原创 MedSci原创

在习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。

代谢综合征(metabolic syndrome,MetS)其实并不是一种疾病。更准确地说,它是一组能使病人易患冠状动脉性心脏病、脑卒中、肾血管及周围血管疾病,以及2型糖尿病的危险因素。具有这些因素的病人的死亡率也比普通人的高。

根据美国国家胆固醇教育计划成人治疗专家组的第三次威廉亚洲博彩公司 (NCEP-ATP III),这些因素包括:

1.    中心性肥胖:腰围>90 cm(我国男性);>80 cm(我国女性);

2.    高甘油三酯血症:空腹血浆甘油三酯浓度≥1.7 mmol/L或150 mg/dL;

3.    低空腹血浆HDL-胆固醇浓度:<1.0 mmol/L或40 mg/dL(男性);<1.3 mmol/L或50 mg/dL(女性);

4.    血压升高:血压≥130/85 mmHg;

5.    胰岛素抵抗:空腹血浆葡萄糖浓度≥5.6 mmol/L或100 mg/dL。

具有3项或更多以上提及的危险因素的病人即可认为其患有MetS。虽然这5项因素各自都是一个独立的危险先兆,但是它们也相互关联,并能相互加强彼此在综合征发展过程中的作用。出现1项以上的危险因素就会增加个体患心血管疾病,脑卒中,及2型糖尿病的危险,所以说它们的共同作用大于它们每项单独作用的总和。

观察性研究表明,摄入坚果与较低的心血管疾病风险有关,而食用精制谷物则与较高的风险有关。对于用坚果代替白米(一种精制谷物)是否会给高风险的成年人带来好处,目前所知甚少。为此,来自中国科学院大学和美国哈佛医学院的营养学专家团队合作对该问题进行了研究。结果发表在营养学顶级杂志《美国临床营养学》(Am J Clin Nutr)杂志上。

该研究是一项平行臂随机对照研究,主要目的是在患有MetS或有MetS风险的参与者中,用花生替代白米条作为零食对空腹血糖、血脂、体重以及MetS变化的影响。共纳入224名参与者,他们要么患有MetS(根据国际糖尿病联盟对中国成年人的标准,n = 163),要么有MetS的风险(中心性肥胖加上1个额外的MetS风险因素,n = 61)。参与者被随机分配到花生组(56g/d作为零食,n = 113)或对照组(等热量白米棒,n = 111)进行为期12周的试验。

共有209名参与者(93.3%)完成了为期12周的干预试验,所有参与者的依从率大于85%。其中,两组参与者空腹血糖、HDL胆固醇、腰围和体重的改善没有明显差异。但花生组参与者的MetS转归率(12周试验后不再符合MetS标准)明显高于对照组(RR:2.33;95%CI:1.10,4.89;P=0.026)。

由此可见,在习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。未来需要进一步进行更大规模的试验来证实这些发现并阐明潜在的生物学机制。

 

参考文献:

Wang D, et al. Replacing white rice bars with peanuts as snacks in the habitual diet improves metabolic syndrome risk among Chinese adults: a randomized controlled trial. Am J Clin Nutr. 2020 Nov 24:nqaa307. doi: 10.1093/ajcn/nqaa307.

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  4. 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  5. 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objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:34:44 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915808, encodeId=119091580837, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d42482870, createdName=12460f22m82暂无昵称, createdTime=Tue Jan 12 09:50:54 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915075, encodeId=1d399150e5d3, content=习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。, beContent=null, 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    2021-06-20 ms7000001124466419

    实用

    0

  6. 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    2021-05-24 qjddjq
  7. 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objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:34:44 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915808, encodeId=119091580837, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d42482870, createdName=12460f22m82暂无昵称, createdTime=Tue Jan 12 09:50:54 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915075, encodeId=1d399150e5d3, content=习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。, beContent=null, 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    2021-02-25 13895086385H一

    有一定道理

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:34:44 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915808, encodeId=119091580837, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d42482870, createdName=12460f22m82暂无昵称, createdTime=Tue Jan 12 09:50:54 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915075, encodeId=1d399150e5d3, content=习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Jan 09 22:14:47 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-02-01 6322400001

    不太信

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210131/b35591bafe2a4b869917b577adba9fab/c267322e38334bd6a95a8340ea85f70c.jpg, createdBy=f36b1426385, createdName=6322400001, createdTime=Mon Feb 01 15:34:44 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915808, encodeId=119091580837, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a5d42482870, createdName=12460f22m82暂无昵称, createdTime=Tue Jan 12 09:50:54 CST 2021, time=2021-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=915075, encodeId=1d399150e5d3, content=习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Jan 09 22:14:47 CST 2021, time=2021-01-09, status=1, ipAttribution=)]
    2021-01-12 12460f22m82暂无昵称

    学习

    0

  10. 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    2021-01-09 三生有幸9135

    习惯性饮食中加入花生作为零食代替精制谷物零食,并没有显著改变血糖或血脂参数,但改善了中国成人心脏代谢疾病高风险人群的整体MetS风险。

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