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庆应义塾大学团队获得iPSCs心肌移植试验的批准

2020-02-08 Allan MedSci原创

庆应义塾大学iPSCs心肌移植
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据《朝日新闻》报道，日本庆应义塾大学的研究人员已获得诱导多能干细胞（iPSCs）衍生的心肌细胞治疗扩张型心肌病的批准。

据《朝日新闻》报道，日本庆应义塾大学的研究人员已获得诱导多能干细胞（iPSCs）衍生的心肌细胞治疗扩张型心肌病的批准。该小组将把京都大学提供的iPSCs细胞转化为心肌细胞，并创建用于移植的心肌球。他们将向每位患者移植5000万个心肌细胞，这是该团队确认的最小数目。三名患者将接受移植，然后该团队将花费一年的时间监测效果，包括接受者是否经历严重的不规则心跳以及移植细胞的成瘤性。

诱导多能干细胞（iPSCs）是一种由哺乳动物成体细胞经转入转录因子等手段脱分化形成的多能干细胞，最早由日本学者山中伸弥的研究团队于2006年发现。iPSCs与胚胎干细胞拥有相似的再生能力，理论上可以分化为成体的所有器官、组织。相比于胚胎干细胞，iPSCs面临的伦理道德争议较小，且应用该技术可以产生基因型与移植受体完全相同的干细胞，规避了排异反应的风险。


原始出处：

https://www.firstwordpharma.com/node/1699077

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    2020-07-20 wfang545

    #庆应义塾大学#

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    2020-02-10 chengjn

    #iPS#

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    2020-02-10 gjsgj

    #PSC#

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    2020-02-10 caoliehu

    #iPSCs#

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    2020-02-10 neurosurgeon

    #iPSC#

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