Lancet Respiratory Medicine:新冠出院一年后,超70%患者仍有后遗症

2022-04-26 医诺维 医诺维

由于缺乏针对新冠后遗症的治疗方法,研究结果强调迫切需要医疗保健服务来支持这一庞大且迅速增加的患者群体,这些患者群体存在大量症状,包括运动能力下降和一年后与健康相关的生活质量大幅下降。

新冠病毒,通常通过呼吸道感染人类,并造成呼吸系统和人体各个器官的损伤。自2019年底首次爆发至今,新型冠状病毒仍在全球肆虐,对世界经济、社会造成极大的负面影响。

疫情两年多以来,williamhill asia 已经认识到,新冠不只是一种呼吸系统疾病,而是会影响人体多个组织和器官。比如影响中枢神经系统,导致嗅觉和味觉丧失、疲劳、认知能力下降,一些患者还会发生中风、意识受损更严重的症状。甚至有一些研究报道,部分年轻人在感染新冠后,出现了帕金森病相关症状,这些都是被称为新冠后遗症的一部分。

2022年4月23日,英国莱斯特大学的研究人员在《柳叶刀》子刊 The Lancet Respiratory Medicine 上在线发表了题为:Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK:a prospective observational study 的研究论文。

这项针对2000多名新冠住院患者的研究表明,感染新冠一年后,仅有29%的患者完全康复,71%的患者有后遗症,最常见的后遗症是疲劳、肌肉疼痛、身体变慢、睡眠不佳和呼吸困难。

在该研究中,研究人员分析了来自39家英国国家卫生服务局(NHS)医院的患者,共纳入2020年3月7日-2021年4月18日期间出院的2320名成年参与者,其中807名(32.7%)参与者在出院后5个月和1年接受了随访评估。平均年龄为59岁,其中279名(36%)为女性,28%接受了有创机械通气。

在出院后5个月和1年,使用患者报告的结果指标、身体表现和器官功能来评估康复情况。研究人员还在为期五个月的访问中采集了参与者的血液样本,以分析其是否存在各种炎症蛋白。

统计分析发现,在出院后5个月,报告完全康复的患者比例为25.5%,在出院1年后完全康复的患者比例为28.9%。

患者在5个月和1年的恢复状态

研究发现,与男性相比,女性完全康复的可能性降低了32%;肥胖的人完全康复的可能性降低了50%;需要机械通气的患者的完全康复的可能性降低了58%。

结果表明,女性、肥胖和在医院接受机械通气都与一年后完全康复的可能性较低有关。最常见的后遗症是疲劳、肌肉疼痛、身体变慢、睡眠不佳和呼吸困难。

患者在5个月和1年的康复结果比较

研究人员表示,在这项研究中,住院后5个月至1年的症状、心理健康、运动能力、器官损伤和生活质量方面的有限恢复是惊人的。

他们还强调,女性和肥胖是1年后无法恢复的主要风险因素,因为女性和肥胖与更严重的持续健康损害有关,包括运动表现和健康相关的生活质量下降。

由于缺乏针对新冠后遗症的治疗方法,研究结果强调迫切需要医疗保健服务来支持这一庞大且迅速增加的患者群体,这些患者群体存在大量症状,包括运动能力下降和一年后与健康相关的生活质量大幅下降。

研究人员说,如果没有有效的治疗方法,新冠后遗症可能会成为一种高度流行的新的长期疾病。

 

原始出处:

Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study. The Lancet Respiratory Medicine, 2022.

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    2023-04-05 jeanqiuqiu
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    2022-11-02 kalseyzl
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    2022-08-16 howi
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    2022-04-27 huirong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1859253, encodeId=0394185925320, content=<a href='/topic/show?id=e0a9593596' target=_blank style='color:#2F92EE;'>#DIC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5935, encryptionId=e0a9593596, topicName=DIC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f7770, createdName=jeanqiuqiu, createdTime=Wed Apr 05 10:52:27 CST 2023, time=2023-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1774051, encodeId=f7b31e74051ea, content=<a href='/topic/show?id=5f014e1852' target=_blank style='color:#2F92EE;'>#CIN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4718, encryptionId=5f014e1852, topicName=CIN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a9a038523631, createdName=kalseyzl, createdTime=Wed Nov 02 01:52:27 CST 2022, time=2022-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831547, encodeId=f1a9183154eb2, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Aug 16 02:52:27 CST 2022, time=2022-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1418829, encodeId=4d2114188299a, content=<a href='/topic/show?id=da8839121bb' target=_blank style='color:#2F92EE;'>#后遗症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39121, encryptionId=da8839121bb, topicName=后遗症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=615b3422729, createdName=huirong, createdTime=Wed Apr 27 09:52:27 CST 2022, time=2022-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577889, encodeId=def315e788931, content=<a href='/topic/show?id=cda91148004' target=_blank style='color:#2F92EE;'>#Medicine#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11480, encryptionId=cda91148004, topicName=Medicine)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=54cd16396700, createdName=ms1692212821629096, createdTime=Wed Apr 27 09:52:27 CST 2022, time=2022-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611556, encodeId=dc1b161155612, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Apr 27 09:52:27 CST 2022, time=2022-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1243984, encodeId=b32d124398461, content=lancet上果然牛,感谢williamhill asia 更新及时, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=younei, createdTime=Mon Apr 25 21:52:27 CST 2022, time=2022-04-25, status=1, ipAttribution=)]
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    2022-04-25 younei

    lancet上果然牛,感谢williamhill asia 更新及时

    0

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